Versatile and Environmentally Friendly New Reaction Methodologies for Synthetic...
Versatile and Environmentally Friendly New Reaction Methodologies for Synthetic Organic Chemistry with Application to Natural Product Synthesis
Enantioselective catalysis is the most important frontier of synthetic organic chemistry today. As nature uses enzymes to catalyze highly stereoselective reactions, it was long assumed that large and complex structures are essenti...
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30/04/2011
UNIVERSITY OF YORK
172K€
Presupuesto del proyecto: 172K€
Líder del proyecto
UNIVERSITY OF YORK
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Fecha límite participación
Sin fecha límite de participación.
Financiación
concedida
El organismo FP7 notifico la concesión del proyecto
el día 2011-04-30
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Información proyecto CASCADES
Líder del proyecto
UNIVERSITY OF YORK
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
172K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Enantioselective catalysis is the most important frontier of synthetic organic chemistry today. As nature uses enzymes to catalyze highly stereoselective reactions, it was long assumed that large and complex structures are essential to attain high enantioselectivity. However, it has now been illustrated by MacMillan and others that small molecule organic catalysts can compete with the enantioselectivity and reactivity levels of enzymes, omitting the need for highly toxic organometallic catalysts or strong Lewis acids. The availability of enantiopure organic chemicals as well as the academic, industrial, environmental and economic benefits of organocatalysis has shown the importance of this field of research. The combination of more than one chemical transformation into a cascade sequence is also an expanding area of research due to the reduction in cost, energy and waste. The proposed outgoing phase project would further the development of a new enantioselective organocatalytic method, within the pioneering research group of Prof. David MacMillan at Princeton. The MacMillan group have consistently been at the forefront of organocatalysis research, and thus far have pioneered over 30 catalytic asymmetric transformations of immense practicality and synthetic utility. The return phase project would highlight the importance of domino reaction sequences in organic synthesis today, with the implementation of a 3-step cascade in the total synthesis of an anti-cancer molecule. The mobility, importance of the research topic and high profile collaboration between 2 world-class research institutes would increase scientific excellence and provide opportunity to widely advertise participation in Marie Curie actions. Overall, a highly motivated European scientist would benefit greatly from both phases whilst developing many new skills. Important networks of international communication would be established, providing a platform for further collaborations in the future.