VascArbor
Financiado
Vascular Tree Formation in Multi Structural Tissue Engineering
Engineered tissues offer a great promise to the field of medicine as an alternative for donor tissues, for which the supply is not meeting the demands. However, the clinical application of engineered tissues is hampered. The integ...
Engineered tissues offer a great promise to the field of medicine as an alternative for donor tissues, for which the supply is not meeting the demands. However, the clinical application of engineered tissues is hampered. The integration of engineered tissues after implantation is limited due to the lack of a vascular network. Currently, strategies to include vascular networks rely on the spontaneous organization of vascular cells, or on the patterning of these cells. However, this results in either vascular networks that are not organized, or networks that lose their initial organization fast. This project will use a unique and novel approach to control vascular development and will therefore result in a vascular network with a controllable long-term organization. By allowing for anastomosis, and increasing nutrient delivery, this project will tackle an essential problem and will greatly enhance the clinical applicability of engineered tissues.
Within VascArbor, fluid flows through engineered tissues will be designed and controlled to guide vascular organization. Apart from that, growth factors will be patterned in space and time to further direct the formation of a vascular network with a controlled organization. In parallel, computational models will be developed that can predict vascular organization and development based on processing parameters. This will be a breakthrough in vascularized tissue engineering by enabling a direct link between a desired vascular organization, and the tissue construct geometry and processing conditions that are needed to acquire this organization.
To maximize the impact of VascArbor on the field of tissue engineering and medicine, the principles that will guide vascular organization are compatible with multiple current and future tissue fabrication technologies. Within VascArbor, tissue building blocks and bio-printing will be used to engineer vascularized cardiac muscle tissue based on the principles developed in this project.
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Duración del proyecto: 62 meses
Fecha Inicio: 2017-01-20
Fecha Fin: 2022-03-31
Fecha Fin: 2022-03-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2022-03-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2016-COG:
ERC Consolidator Grant
Cerrada
hace 8 años
Presupuesto
El presupuesto total del proyecto asciende a
2M€
Líder del proyecto
UNIVERSITEIT TWENTE
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
355.74K€ |
Participante