Innovating Works

open-TOP

Financiado
Validation of Open organ on chip Technology for End user applications
Organ-on-Chips, and more general microphysiological systems, are believed to revolutionize the way we develop drugs or select personalized therapies. Recapitulating human response both from healthy and diseased individuals potenti... Organ-on-Chips, and more general microphysiological systems, are believed to revolutionize the way we develop drugs or select personalized therapies. Recapitulating human response both from healthy and diseased individuals potentially even enables ‘clinical trials in-a-dish’. While research in this field is thriving and commercial start-ups have been founded, adoption from end users is staying behind due to a number of reasons: i) lack of standardization making chips not compatible with each other, ii) lack of automation which limits the throughput and user-friendliness of the systems and iii) lack of support for sensor integration. The Twente Organ-on-Chip Platform (TOP) is designed to overcome these hurdles and has been developed for internal use during the ERC project VESCEL. During interaction with other researchers and companies within the Organ-on-Chip field they expressed their interest in a more standardized, automated platform that also supports sensor integration. Since it would require a number of steps for them to be able to use the platform in their existing environment we here suggest the ‘open-TOP’ ERC Proof of Concept project where we aim to commercialize the application of the Twente Organ-on-Chip Platform (TOP) and facilitate end users to use TOP in real world contexts. To reach this objective we need to develop a robust interconnect, validate and identify difficulties in making a third party chip TOP-compatible, validate the use of TOP for a biological experiment and finally determine the commercialization strategy for TOP. We believe TOP can help more end users to adopt Organ-on-Chip as a technology in their lab because in contrast to current setups, the open technology of TOP supports chips from third parties are inter compatible, multiplexable and controlled automatically. If ‘open-TOP’ is granted, TOP will be the standardized Organ-on-Chip infrastructure allowing users to stop worrying about control systems and only focus on chips and biology. ver más
31/08/2022
UNIVERSITEIT TWENT...
150K€
Duración del proyecto: 26 meses Fecha Inicio: 2020-06-17
Fecha Fin: 2022-08-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2022-08-31
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2019-POC: ERC Proof of Concept Grant
Cerrada hace 5 años
Presupuesto El presupuesto total del proyecto asciende a 150K€
Líder del proyecto
UNIVERSITEIT TWENTE No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5