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Ageing with elegans

Financiado
Validating C. elegans healthspan model for better understanding factors causing...
Validating C. elegans healthspan model for better understanding factors causing health and disease to develop evidence based prevention diagnostic therapeutic and other strategies. Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic... Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors. ver más
31/10/2020
KU Leuven
7M€
Duración del proyecto: 66 meses Fecha Inicio: 2015-04-09
Fecha Fin: 2020-10-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2020-10-31
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
PHC-01-2014: Understanding health, ageing and disease: determinants, risk factors and pathways
Cerrada hace 10 años
Presupuesto El presupuesto total del proyecto asciende a 7M€
Líder del proyecto
KATHOLIEKE UNIVERSITEIT LEUVEN No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5