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NotToKill-NotToDie

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Unrevealing dry season Plasmodium falciparum replication biology

Plasmodium falciparum is responsible for over 200 million yearly malaria cases and the major burden is upon African children. Public health strategies to control and ultimately eradicate malaria are very much needed. In Africa, se... ver más

30/06/2021

UKHD

175K€

Presupuesto del proyecto: 175K€

Líder del proyecto

UNIVERSITATSKLINIKUM HEIDELBERG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-06-30

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UKHD

174.81K€ | Lider

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Duración del proyecto: 26 meses Fecha Inicio: 2019-04-17
Fecha Fin: 2021-06-30

Líder del proyecto

UNIVERSITATSKLINIKUM HEIDELBERG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 175K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Plasmodium falciparum is responsible for over 200 million yearly malaria cases and the major burden is upon African children. Public health strategies to control and ultimately eradicate malaria are very much needed. In Africa, seasonal transmission of this mosquito-borne parasite is very common. Infections in adults are clinically silent whilst in children it generally leads to clinical disease with nearly half a million deaths each year. The dry season represents a major challenge for the parasite’s survival due to the absence of the transmission vector; yet, P. falciparum seems to be capable of maintaining low parasitemias just enough not to kill but not to die. During the dry season, an important fraction of these children remains clinically silent for months despite the decrease in P. falciparum-specific antibody levels. This low parasitemia reservoir is indispensable to spread transmission in the following rainy season. How do parasites not increase to the point of causing clinical malaria in these children during the dry season? We hypothesize that during the dry season with no mosquitoes available to transmit, continuous rounds of P. falciparum blood stage replication lead to a differential gene expression related to cell cycle progression allowing the maintenance of low levels of parasitemia. The Center for Infectious Diseases, University Hospital Heidelberg has an interdisciplinary and translational orientation and is embedded in partnerships with groups in malaria endemic countries, representing a unique environment to execute the objectives of this project. I offer translational expertise in the malaria from my previous experience in malaria endemic areas of Brazil as well as in state-of-the-art laboratories in the US. This ambitious yet feasible project also offers the opportunity for me to broaden my expertise in malaria by acquiring knowledge in new area, which will allow me to build a solid background from which to become an independent researcher.

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