MS
Financiado
Unravelling the molecular and cellular mechanism of metastasis
Metastasis is the primary cause of cancer deaths. For most cancers, the identification and the mechanisms by which the metastatic initiating cells (MICs) successfully establish a secondary tumour at a distant site from their prima...
Metastasis is the primary cause of cancer deaths. For most cancers, the identification and the mechanisms by which the metastatic initiating cells (MICs) successfully establish a secondary tumour at a distant site from their primary tumour remains elusive (1). New animal models are needed to better understand the clonal dynamic and molecular mechanisms guiding different steps of the metastatic cascades in vivo, given the tremendous heterogeneity of tumours (2-7) and the limited capacity to trace multiple genetic clones in parallel with the traditional reporter mice (8). This will aid the design of new methods for early diagnosis and the monitoring of patients with metastasis, as well as the development of new strategies that target or prevent metastasis.
In this project, I will use clonal lineage tracing with Poly-Lox reporter that enables tracing of over 200’000 clones (9) and confetti reporter (10) combined with single cell transcriptional profiling in order to define the cellular and molecular mechanisms that regulate the metastatic cascade in vivo in two different mouse models of squamous cell carcinoma and breast tumour. With the immunostaining, FACS and single cell sequencing analyses I will study the role of various fibroblast sub-populations in affecting the extravasion and establishment of tumour cells at the site of metastasis.
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Duración del proyecto: 35 meses
Fecha Inicio: 2019-04-15
Fecha Fin: 2022-04-03
Fecha Fin: 2022-04-03
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2022-04-03
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2018:
Individual Fellowships
Cerrada
hace 6 años
Presupuesto
El presupuesto total del proyecto asciende a
178K€
Líder del proyecto
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
No se ha especificado una descripción o un objeto social para esta compañía.
223.44K€ |
Participante