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Host Sweet Home

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Unravelling the mechanisms that allow endosymbionts to make themselves at home w...

Unravelling the mechanisms that allow endosymbionts to make themselves at home within hosts from transfer to transit. Endosymbiotic bacteria are usually not infectious, they have been thought to exclusively transfer vertically from the host mother to her offspring. Consequently we do often observe congruence between the phylogenetic trees of endo... ver más

31/10/2021

LUNDS UNIVERSITET

186K€

Presupuesto del proyecto: 186K€

Líder del proyecto

LUNDS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-10-31

MSCA-IF-2017: Individual Fellowships

I+D

Cerrada hace 7 años

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1 Participantes

LUNDS UNIVERSITET

185.86K€ | Lider

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Duración del proyecto: 43 meses Fecha Inicio: 2018-03-13
Fecha Fin: 2021-10-31

Líder del proyecto

LUNDS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 186K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Endosymbiotic bacteria are usually not infectious, they have been thought to exclusively transfer vertically from the host mother to her offspring. Consequently we do often observe congruence between the phylogenetic trees of endosymbiotic bacteria and their host species, but not always. Evidences for the horizontal transfer of endosymbiotic bacteria between highly divergent host species have recently been accumulating, especially from studies in Insects. My own research on this topic led me to hypothesise that endosymbiotic strains not transferring horizontally may have lost the ability to do so and to establish into naïve hosts, contrasting to strains found in divergent host species. Instead of transferring, these strains would transit from a generalist state, able to jump and establish into naïve hosts, towards a more specialist state found in only few host species. Using Wolbachia bacteria-butterfly host associations and a multidisciplinary approach, I aim at (I) testing the evolutionary relevance of horizontal transfer of symbionts, (II) phenotypically characterizing generalist and specialist symbionts, and (III) identifying the molecular bases to the establisment of symbiosis. The novelty of this project lies into solving the dilemma associated to the endosymbiotic lifestyle: to maintain the mechanisms allowing transfer between hosts or to transit towards a specialised relationship with the host. ‘Host Sweet Home’ will to unravel the evolutionary history, and the constraints and outcomes of endosymbiosis. I will produce a large amount of genetic data, which analysis will result in highly significant research in the field of symbiosis, with a potential impact beyond the field of Evolutionary Ecology.

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