Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MinSynCell

Financiado

Unravelling the chemical-physical principles of life through minimal synthetic c...

Unravelling the chemical-physical principles of life through minimal synthetic cellularity A grand challenge in bottom-up synthetic biology is to design and construct synthetic cells with life-like properties from a minimal number of parts. Achieving this goal would be a major engineering feat and enable an understandin... ver más

30/09/2028

USAAR

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITAT DES SAARLANDES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-09-05

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

2 Participantes

USAAR

1.90M€ | Lider

MPG

101.45K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ENZYME-DCC Enzyme-Mediated Dynamic Combinatorial Chemistry 1M€ Cerrado

PID2019-106327GA-I00 QUIMICA ORGANICA FUERA DEL EQUILIBRIO: SISTEMAS QUIMICOS COM... 85K€ Cerrado

PID2020-113181GB-I00 ESPACIOS CONFINADOS FLEXIBLES PARA QUIMICA BIOINSPIRADA 103K€ Cerrado

DarChemDN Darwinian Chemistry Doctoral Network 3M€ Cerrado

PRE2020-095493 QUIMICA ORGANICA FUERA DEL EQUILIBRIO: SISTEMAS QUIMICOS COM... 99K€ Cerrado

SYNSEMBL Cell-free synthesis and assembly of biomolecular condensates... 2M€ Cerrado

Duración del proyecto: 60 meses Fecha Inicio: 2023-09-05
Fecha Fin: 2028-09-30

Líder del proyecto

UNIVERSITAT DES SAARLANDES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto A grand challenge in bottom-up synthetic biology is to design and construct synthetic cells with life-like properties from a minimal number of parts. Achieving this goal would be a major engineering feat and enable an understanding of how living systems work from the perspective of physical chemistry. Towards this, we have exploited bottom-up approaches and generated new insights into the impact of compartmentalization on the thermodynamics and kinetics of incorporated enzyme reactions. Our findings that dynamic coacervation can ignite dormant enzyme reactions provides the conceptual framework for our plan to build sustained out-of-equilibrium synthetic cellular systems. In MinSyn, the aims are to: 1) Define how molecular reaction networks are tuned by compartmentalization. 2) Build minimal synthetic compartments with self-sustained, out-of-equilibrium behaviour. 3) Utilize communication to coordinate reaction networks within populations of cells. Together, these objectives test our overarching hypothesis that sustained out-of-equilibrium systems can be established by interconnecting three features: molecular reaction networks, compartmentalization and communication. Key to this endeavour is our unique combination of chemical, biochemical and biophysical tools for quantitative characterization of synthetic cellular systems. We are primed to address the major engineering challenge of building sustained out-of-equilibrium synthetic cellular systems and to tackle a central problem in biological sciences: How do biological cells and tissues sustain life from collections of non-living molecules? Our interdisciplinary approach will provide novel tools to the community and represents a unique multidisciplinary approach that will ultimately define the chemico-physico parameters of life. This can lead to unprecedented opportunities to rationally engineer molecular systems which may supersede biological capabilities.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores