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Mel.Photo.Protect

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Unraveling the Photoprotecting Mechanism of Melanin From a Library of Fragment...

Unraveling the Photoprotecting Mechanism of Melanin From a Library of Fragments to Simulation of Spectra and Function Melanin is the deeply coloured, insoluble and heterogenous biopolymer of animal skin, hair and eyes responsible for protection against harmful light action. It also has a pathogenic role as a generator of reactive oxygen species a... ver más

31/08/2021

UDG

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

UNIVERSITAT DE GIRONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 227

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-08-31

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UDG

172.93K€ | Lider

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Duración del proyecto: 28 meses Fecha Inicio: 2019-04-10
Fecha Fin: 2021-08-31

Líder del proyecto

UNIVERSITAT DE GIRONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 227

Presupuesto del proyecto 173K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Melanin is the deeply coloured, insoluble and heterogenous biopolymer of animal skin, hair and eyes responsible for protection against harmful light action. It also has a pathogenic role as a generator of reactive oxygen species and possibly through chemiexcitation, and its polydopamine synthetic analogue has raised great interest in the materials community. In spite of these multiple points of interest, the details of melanin structure and its main photoprotecting function are still largely unknown, mostly due to the heterogeneous polymer structure. Closing this gap is an urgent challenge, and our proposal aims at doing that with the methods of computational chemistry. Based on the widely accepted hierarchical structure model for melanin, in WP1 we will generate a library of aggregates made of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oligomers with different connectivity and redox state (diol, semiquinone and quinone forms). In WP2 we will simulate the absorption spectra of the aggregates and compare them with the experimental melanin spectrum, which starts at the near IR and increases monotonically into the UV. In WP3 we will simulate the excited-state decay mechanisms for the different aggregates in order to explain melanin's lack of fluorescence, which is indicative of fast decay responsible for its photoprotecting function. The results of our project will provide a new view on the photoprotecting function of melanin based on a systematic consideration of its heterogeneous structure, and they will allow us to assess what specific aggregates are responsible for the different functional characteristics. They will help us to assess the possible pathogenic role of melanin chemiexcitation, and provide new principles for design of PDA-based functional materials.

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