Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

Photochem-RS-RP

Financiado

Unraveling the Photochemistry of Radiosensitizers and Radioprotectors in Free Bi...

Unraveling the Photochemistry of Radiosensitizers and Radioprotectors in Free Biomolecular Complexes Dramatically increasing cancer cases around the world call for extra research efforts to improve cancer therapies. Radiation therapy or radiotherapy is one of the most common treatment methods. A way to enhance radiotherapy is ins... ver más

30/06/2024

231K€

Presupuesto del proyecto: 231K€

Líder del proyecto

AARHUS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-06-30

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

230.77K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2019-104727RB-C22 EFECTO RADIOBIOLOGICO DE RADICALES Y RADIOSENSIBILIZADORES M... 16K€ Cerrado

NuCapCure Development of innovative proton and neutron therapies with... 6M€ Cerrado

PID2019-104727RB-C21 EFECTO RADIOBIOLOGICO DE RADICALES Y RADIOSENSIBILIZADOES MO... 156K€ Cerrado

RTI2018-101578-B-C22 EFECTOS RADIOBIOLOGICOS DE PULSOS DE PARTICULAS ULTRA-INTENS... 48K€ Cerrado

RADIOBIO Deciphering the radiobiology of targeted radionuclide therap... 2M€ Cerrado

ATR2023-143812 Física de partículas y nuclear 842K€ Cerrado

Duración del proyecto: 25 meses Fecha Inicio: 2022-05-29
Fecha Fin: 2024-06-30

Líder del proyecto

AARHUS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 231K€

Descripción del proyecto Dramatically increasing cancer cases around the world call for extra research efforts to improve cancer therapies. Radiation therapy or radiotherapy is one of the most common treatment methods. A way to enhance radiotherapy is inserting ‘radiosensitizers (RSs)’ and ‘radioprotectors (RPs)’ into the patient’s body. RSs in tumor cells make them more sensitive to radiation damage, allowing one to use reduced radiation doses, thus minimizing side effects. In contrast, RPs inhibit the damage of healthy cells from radiation. RSs and RPs are actively studied mostly in clinical trials. However, the fundamental mechanisms causing damage or death of cancer cells are not fully understood. Therefore, this project aims at elucidating the elementary steps of radiation damage, their enhancement by RSs, and their inhibition by RPs. The technique combines beams of mixed molecular clusters and doped helium nanodroplets uniquely with synchrotron spectroscopy, electron spectroscopy, and ion mass spectrometry. The main goals are to unravel the photochemistry of selected organic RS compounds (nimorazole, NIMO, bromoadenine, WR-1065 dihydrochloride), metal ions (Mg2+, Ca2+, K+), and gold (RS) and silver (RP) nanoparticles in the state of controlled microhydration and contact with DNA components (thymine, cytosine, tetrahydrofuran). Emission of slow electrons, water fragmentation, and anions formation are observables for radiation damage enhanced by RSs. A time-resolved experiment on the tetrahydrofuran-water complex will elucidate the ultrafast dynamics of intermolecular energy transfer causing dissociation, a mechanism recently identified to play an important role in radiation damage. A better understanding of the radiochemistry of RPs and RSs obtained with this project may help develop new schemes for efficient cancer treatment and identify new types of molecules or nanoparticles with improved RS or RP properties.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores