Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FLAVIR

Financiado

Universal building blocks for antigen presentation to uncover the flavivirus-dir...

Universal building blocks for antigen presentation to uncover the flavivirus-directed antibody response Flaviviruses are a tremendous burden on global public health. The genus consists of yellow fever virus, dengue virus, and zika virus amongst others. These viruses threaten more than half the global human population and are spreadi... ver más

31/07/2028

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-11

ERC-2022-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

1.69M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PROACTIVE PROposing Action to ConTrol and Impede betacoronaVirus Emerg... 2M€ Cerrado

Yellow4FLAVI Deconstructing the protective immunity of yellow fever virus... 8M€ Cerrado

EUR2022-134042 EL PAPEL DE LAS MUTACIONES FENOTIPICAS EN LA EVASION DE ANTI... 90K€ Cerrado

REVAMP REVisiting Antibody structures and repertoires through advan... 3M€ Cerrado

UNIFLUVAC A novel universal influenza vaccine targeting epitopes of li... 149K€ Cerrado

SAF2015-66193-R UTILIZACION DE MEDICINA DE SISTEMAS PARA LA PREDICCION DE LA... 182K€ Cerrado

Duración del proyecto: 63 meses Fecha Inicio: 2023-04-11
Fecha Fin: 2028-07-31

Líder del proyecto

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Flaviviruses are a tremendous burden on global public health. The genus consists of yellow fever virus, dengue virus, and zika virus amongst others. These viruses threaten more than half the global human population and are spreading into new territories. The recent zika virus pandemic stresses the need for a suitable protein engineering toolkit to enable swift development of emerging flavivirus antigens for structural studies, serology and vaccine development. Moreover, the structural determinants of a neutralizing polyclonal antibody response are currently not well understood, in large part for a lack of suitable methods to address the complex interactions of multiple antibodies directed against a heterogeneous, glycosylated viral antigen. With FLAVIR I will use my unique expertise in both mass spectrometry and electron microscopy to develop a comprehensive structural proteomics toolkit for in-depth profiling of the neutralizing antibody response against flaviviruses. Using a combination of novel mass spectrometry-based antibody sequencing techniques, glycoproteomics profiling and electron microscopy, we will uncover how the polyclonal antibody response against flaviviruses is directed by key structural determinants of the Envelope glycoprotein that is displayed on the surface of infectious virions. We will develop new strategies to produce prefusion stabilized E-dimers and ultimately reconstruction of full icosahedral flavivirus-like particles from soluble components. The outlined strategies will be tested and streamlined for broad applicability across the flaviviruses so that it can be swiftly adapted for emerging species and strains. We will characterize our designs with state-of-the art mass spectrometry methods (native MS, mass photometry, HDX-MS) and electron microscopy. We will use these optimized antigens to uncover the role of antigen glycosylation in antibody binding, profile the serum antibody repertoire directed against the E-antigen and map ou

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores