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ErasingFear

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Understanding the Stability and Plasticity of Emotional Memory

The breakthrough discovery in animal research that fear memories may change upon retrieval – referred to as memory reconsolidation – has drastically changed the view on the malleability of emotional memory. Inspired by these insig... ver más

31/12/2024

UvA

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITEIT VAN AMSTERDAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-12-31

ERC-2016-ADG: ERC Advanced Grant

I+D

Cerrada hace 8 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UvA

2.50M€ | Lider

HAM CRIOGENICA

300.99K€ | Participante

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Duración del proyecto: 85 meses Fecha Inicio: 2017-11-13
Fecha Fin: 2024-12-31

Líder del proyecto

UNIVERSITEIT VAN AMSTERDAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The breakthrough discovery in animal research that fear memories may change upon retrieval – referred to as memory reconsolidation – has drastically changed the view on the malleability of emotional memory. Inspired by these insights, we have developed a novel approach to pharmacologically erase the affective component from fear memories in humans. Although these findings suggest a paradigm shift in clinical practice, there are many fundamental questions to be resolved. The objective of this proposal is to gain an in-depth, comprehensive understanding of the dynamic balance between the stability and malleability of emotional memory, and consequently develop a revolutionary theory-driven treatment for emotional memory disorders. This program presents a novel mechanistic framework on memory reconsolidation challenging in several ways the dominant model of emotional memory modification. First, while during traditional interventions cognitive changes are required for a reduction in fear, in our procedure cognitive changes preclude the neutralization of fear memory. On the other hand, post-retrieval changes in the cognitive (WP1) and neural (WP2) expression of fear memory may serve as read-outs to demarcate the underlying processes necessary for memory reconsolidation. Second, in contrast to the immediate, but gradual decline of fear during traditional interventions, with memory reconsolidation the fear reduction is delayed, yet abrupt, and sleep may be essential (WP3). A thorough understanding of these processes is essential for developing a reconsolidation intervention in clinical practice (WP4). Finally, the program aims to understand the paradoxical dissociation, yet interdependence, between the cognitive and emotional expressions of fear memory (WP5). This proposal is unique in its bidirectional translational approach. It involves different levels of analysis: from behavioural science, to neuroscience to clinical science, and backwards.

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