Hola,
Are you new here?

I have an account

¿Te ayudamos?

Ejemplos de búsqueda

Vídeos Explicativos

NanoGlia

financed

Closed

Understanding the impact of nanoplastics on the development of neurological diso...

Understanding the impact of nanoplastics on the development of neurological disorders An omnipresent but understudied environmental risk for our immune system is pollution by nano-sized plastics. Plastic particles have been detected in a wide variety of ecosystems and are speculated to enter and spread in the food... see more

31/03/2026

RHEINISCHE FRIEDRI...

1M€

Project Budget: 1M€

Project leader

RHEINISCHE FRIEDRICHWILHELMSUNIVERSITAT BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 2 Participantes

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-01-23

ERC-2019-STG: ERC Starting Grant Scope:Objectives

I+D

Cerrada does 6 years

0% 100% 100%

characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

RHEINISCHE FRIEDRICHWILHELMS...

1.50M€ | Leader

PRORETINA THERAPEUTICS

600.00K€ | participant

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Project duration: 74 months Date Start: 2020-01-23
End date: 2026-03-31

Project leader

RHEINISCHE FRIEDRICHWILHELMSUNIVERSITAT BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description An omnipresent but understudied environmental risk for our immune system is pollution by nano-sized plastics. Plastic particles have been detected in a wide variety of ecosystems and are speculated to enter and spread in the food web all the way to humans. Ingested nanoplastics can translocate from the gut to the lymph and circulatory systems and have the capacity to cross the blood-brain barrier in mammals. It has been recently shown that nanoplastics cause behavioural disorders in fish, and thus may also represent a risk for human health, in particular for brain function. However, the long-term bioavailability and toxicity of nanoplastics in the brain are unknown. Microglia as the main neuroimmune cells have not only a defence function required during inflammatory conditions, but constantly sense and response to environmental changes as part of their housekeeping functions that are essential for neuronal homeostasis. This places microglia at the interface between normal and abnormal brain development and function. In line with this, we have recently discovered that chronic microglial activation causes neurodegeneration. As highly phagocytic cells, microglia internalize nanoplastics reaching the brain. This process might in turn lead to their acute or chronic activation, thereby triggering neurological disorders. In NanoGlia, we will use rodent animal models to investigate behavioural as well as cellular and molecular changes in the brain that occur upon ingestion of nanoplastics. We will further determine nanoplastics-induced developmental reprogramming events in fetal microglia that may influence brain organogenesis and function. Understanding how nanoplastics triggers microglial activation during embryogenesis and postnatal stages and whether this immune activation leads to permanent changes in brain development and function will reveal ground-breaking mechanistic insights into the environmentally triggered pathogenesis of neurological disorders.

Conecta tu I+D

Entra hoy

Forgot your password?

Financing

Companies

CTIs/Universidades

Projects

researchers