Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

conNEctoER

Financiado

Cerrado

Understanding of the Membrane Connection Linking the Nucleus to the Endoplasmic...

Understanding of the Membrane Connection Linking the Nucleus to the Endoplasmic Reticulum Compartmentalization into membrane-bound organelles is a key feature of all eukaryotic cells, and communication between organelles needs to be tightly controlled. A key organelle for the inter-organelle communication is the endopl... ver más

31/03/2029

MEDIZINISCHE UNIVE...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

MEDIZINISCHE UNIVERSITAET WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-01

ERC-2023-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 1 año

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

MEDIZINISCHE UNIVERSITAET WI...

Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

OrgaNet From Isolated Compartments to Intracellular Networks Deciph... 1M€ Cerrado

NUCENV Nuclear Envelope Biogenesis Function and Dynamics 3M€ Cerrado

PID2021-122119NB-I00 ARQUITECTURA DE LA VIA DE SECRECION Y CORDINACION SECRETORA-... 339K€ Cerrado

MCS-MD The Molecular Dynamics of Membrane Contact Sites 1M€ Cerrado

PID2019-106232RB-I00 DINAMICA ESPACIO-TEMPORAL DE LOS SITIOS DE CONTACTO ENTRE ME... 157K€ Cerrado

BFU2008-00477 TRAFICO INTRACELULAR NO MEDIADO POR VESICULAS: PAPEL DE LOS... 121K€ Cerrado

Duración del proyecto: 59 meses Fecha Inicio: 2024-04-01
Fecha Fin: 2029-03-31

Líder del proyecto

MEDIZINISCHE UNIVERSITAET WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Compartmentalization into membrane-bound organelles is a key feature of all eukaryotic cells, and communication between organelles needs to be tightly controlled. A key organelle for the inter-organelle communication is the endoplasmic reticulum (ER), which is the major site of lipid and membrane protein synthesis. The ER exchanges molecules by forming stable contact sites with multiple organelles such as mitochondria via specific tethering proteins and transporters. In contrast to these contact sites, the ER is linked to the nucleus via direct fusion to the outer nuclear membrane of the nuclear envelope (NE). These ER-NE junctions are essential for supplying the lipids and proteins that are synthesized in the ER to the NE. Hence, nuclear function and morphology depend on the proper communication via ER-NE junctions. However, the biogenesis, architecture and maintenance of ER-NE junctions have remained elusive.We have recently found that ER-NE junctions exhibit a narrow and constricted ultrastructure during the cell cycle in mammalian cells. These observations led us to postulate that ER-NE junctions are formed and maintained by specific membrane-shaping proteins that are crucial for nuclear function. Here, we propose to identify the molecular mechanism that governs the structure and function of ER-NE junctions. We will provide a quantitative and dynamic high-resolution view of these enigmatic structures by combining time-resolved electron microscopy and quantitative live imaging with molecular perturbations. Using these datasets, we aim to develop a mechanistic model of how ER-NE junctions form and contribute to nuclear function.The NE proteins supplied via ER-NE junctions have critical roles in gene expression, nuclear organization, and nuclear pore biogenesis, as well as in differentiation, development, and disease. Therefore, our research will provide a new conceptual framework that will open lines of investigation in many fields beyond ER/NE biology.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores