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DarkCellFader

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Uncovering the role and regulation of 3D DNA-RNA nuclear dynamics in controlling...

Uncovering the role and regulation of 3D DNA-RNA nuclear dynamics in controlling cell fate decisions At the onset of mammalian life, the first lineage specification decision is made where embryonic cells opt to become either part of the placenta or the future body. Proper regulation of this choice is crucial for subsequent develo... ver más

31/05/2028

IMBA

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-07

ERC-2022-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

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1 Participantes

IMBA

1.50M€ | Lider

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Duración del proyecto: 61 meses Fecha Inicio: 2023-04-07
Fecha Fin: 2028-05-31

Líder del proyecto

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto At the onset of mammalian life, the first lineage specification decision is made where embryonic cells opt to become either part of the placenta or the future body. Proper regulation of this choice is crucial for subsequent development. However, we don’t know how the transcription program and 3D genome architecture arise, interconnect, and are controlled to determine the fate of each cell in a developing embryo. Recent studies, including my work, suggest that in addition to canonical mRNA-coding genes, RNAs from the dark parts of the genome (e.g., transposons, repeats, long-non-coding RNAs) play a significant role during these events, yet how specific classes of RNA regulate gene expression and nuclear architecture post fertilization remains elusive. The main aim of my proposal is to understand the interrelationship between 3D genome organization and the transcriptome across early development and to identify novel factors that lead to the first cell-fate decision and concomitant decrease in cell potency. Recent technical advances, which I co-developed, enabled simultaneous measurement of 3D genome organization and the transcriptome, and facilitated large-scale functional screens in early mammalian embryos. Thus, I now propose to generate spatiotemporal maps of 3D DNA and RNA organization from early mouse embryos at single-cell resolution (Obj.1) to build a complete picture of the relationships between nuclear architecture and emerging cell-type specific transcriptome that drive early cell fate choices. I will combine these data with large-scale in vivo perturbations targeting protein coding genes (Obj.2) and dark genome RNAs (Obj.3) to identify key inducers/regulators of lineage specification and to determine molecular mechanisms governing cell-state transitions. The proposed research will help us to control, correct, and eventually employ early stages of embryonic development and their high cell potency in vitro in reproductive medicine and stem cell research.

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