Hola,
Are you new here?

I have an account

Conecta con

+150K Projects

+300K Companies

+230 Financiaciones

¿Te ayudamos?

Ejemplos de búsqueda

Vídeos Explicativos

ProtMechanics-Live

financed

Closed

Uncovering Protein Mechanics in Physiology and Disease

Protein mechanics is a key contributor to the form and function of biological systems by mechanisms that are just starting to be unraveled. An ensuing hypothesis is that alteration of protein mechanics can trigger disease, particu... see more

31/05/2026

CENTRO NACIONAL DE...

2M€

Project Budget: 2M€

Project leader

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASC... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 28M€

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 2 Participantes

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2021-02-16

ERC-2020-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada does 5 years

0% 100% 100%

characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

CENTRO NACIONAL DE INVESTIGA...

2.00M€ | Leader

JESUS DEL PERDON-BODEGA YUNT...

650.59K€ | participant

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Project duration: 63 months Date Start: 2021-02-16
End date: 2026-05-31

Project leader

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASC... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 28M€

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description Protein mechanics is a key contributor to the form and function of biological systems by mechanisms that are just starting to be unraveled. An ensuing hypothesis is that alteration of protein mechanics can trigger disease, particularly in mechanical conditions such as cardiomyopathies in which primordial underlying molecular mechanisms remain elusive. Although tempting, this possibility has not been tested due to the absence of methods that can modulate the mechanics of proteins in vivo. My proposal aims to overcome technical barriers to scientific progress by establishing manipulation of protein mechanics in living cells and animals as a new research field. In aim 1, we will address current technological limitations through the generation of genetic, protein-engineering-based mechanical loss- and gain-of-function models to interfere acutely and reversibly with protein mechanics in living systems (mLOF and mGOF, respectively). We will apply these first-of-their-kind tools to the giant protein titin, a major contributor to the force-generating and sensing properties of cardiomyocytes with strong links with heart disease, and a workhorse protein that has been instrumental in the past to understand the biophysics of polypeptides under force. In aim 2, we will exploit cellular mLOF and mGOF to define how perturbations of titin mechanics result in altered cardiomyocyte force generation, mechanosensing, mechanotransduction, differentiation and proliferation. Leveraging on our cell studies, in aim 3 we will use murine mLOF and mGOF to shed light into the contribution of titin mechanics to the onset and progression of genetic and acquired cardiomyopathy. ProtMechanics-Live builds on our unique expertise in protein mechanics and engineering, biophysics, biochemistry and cardiovascular biology to enable investigation of mechanical proteins in their functionally relevant, physiological context

Conecta tu I+D

Entra hoy

Forgot your password?

Financing

Companies

CTIs/Universidades

Projects

researchers

What is innovating.Works? Lose yourself in the best search engine for innovative companies you've ever seen, see how your competition is funded, connect with that partner you didn't know about, discover R&D projects that need you, and much, much more just a click away.

Smart Company-Financial Motor Innovating tiene un perfil tecnológico financiero de 400.000 empresas gracias al cual sabe a qué ayuda puede ir o no cualquier empresa de forma automática. Parece magia pero es tecnología.

Create your project and find partners ¿Tienes un proyecto y buscas un partner? Una Universidad, Centro Tecnológico, Consultoría? Este es tu sitio. Gracias al motor de búsqueda podemos recomendarte los mejores socios y ponerte en contacto con ellos.