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U-BIOPRED

financed

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Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes

RationaleThe inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-c... see more

30/09/2015

NOVARTIS

27M€

Project Budget: 27M€

Project leader

NOVARTIS PHARMA AG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 34 Participantes

Financing granted El organismo FP6 notifico la concesión del proyecto The day 2015-09-30 We do not have the information of the call

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

34 Participantes

NOVARTIS

Leader

ALMIRALL

N.D. | participant

UNITOV

N.D. | participant

Pfizer RD UK Limited

N.D. | participant

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Project duration: 71 months Date Start: 2009-10-01
End date: 2015-09-30

Project leader

NOVARTIS PHARMA AG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 27M€

participation deadline Sin fecha límite de participación.

Project description RationaleThe inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.HypothesisThe use of biomarker profiles comprised of various types of high-dimensional data, integrated with an innovative systems biology approach into distinct phenotype handprints, will enable significantly better prediction of therapeutic efficacy than single or even clustered biomarkers of one data type and will identify novel targets.StrategyU-BIOPRED proposes a staged-strategy:I)Generating an international consensus on diagnostic criteria for severe asthma.II)Unbiased discovery of sub-phenotypes of severe asthma in adult and paediatric patient cohorts using biomarker profiles (fingerprints”) and systems biology to define phenotype/handprints”.III)Validating the handprints for exacerbations, disease progression, and experimental challenges.IV)Using the handprints to improve human/animal in vivo and ex vivo models.V)Establishing the responsiveness and predictability of the handprints in gold standard and experimental therapeutic interventions.VI)Refinement of the diagnostic criteria and definition of severe asthma sub-phenotypes by incorporating the handprints, thereby enabling more focused drug development and faster delivery proof of concept for novel drugs.VII)Education, training and dissemination through a stakeholder platform and academic-industrial exchange, with potential for further growth as appropriate.Innovative approachWe will use a novel systems biology approach to integrate high dimensional data from invasive, non-invasive and patient-reported outcomes. All studies will include academic and EFPIA partners as active contributors.

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