Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HUNTING-BrainFibrils

Financiado

Ultrastructural analysis of mutant Huntingtin fibrils extracted from human brain...

Ultrastructural analysis of mutant Huntingtin fibrils extracted from human brain tissue using high-resolution bioimaging and proteomics methods. The formation of protein fibrils in the brain is the most representative feature of neurodegenerative diseases. A detailed description of their structure and composition is essential to design new therapeutic approaches that allow... ver más

31/08/2025

MDC

174K€

Presupuesto del proyecto: 174K€

Líder del proyecto

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-30

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

MDC

173.85K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

tR-GET HD Contribution of tRNA fragments in the ETiopathogenesis of Hu... 181K€ Cerrado

SAF2012-34177 CONVERGENCIA DE ALTERACIONES GENICAS, TRANSCRIPCIONALES Y TR... 386K€ Cerrado

PROPITIOUS Liquid liquid phase separation mediated protein fibrillation... 171K€ Cerrado

PID2020-119386RB-I00 IDENTIFICAR LOS MECANISMOS CONVERGENTES ACTIVADOS POR LA HUN... 278K€ Cerrado

PID2020-116474RB-I00 DESCIFRANDO EL PAPEL DE LA METILACION M6A DEL ARN COMO UN NU... 169K€ Cerrado

SAF2015-65371-R ALTERACIONES EN EL PROCESAMIENTO DEL ARN EN LA ENFERMEDAD DE... 460K€ Cerrado

Duración del proyecto: 36 meses Fecha Inicio: 2022-08-30
Fecha Fin: 2025-08-31

Líder del proyecto

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 174K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The formation of protein fibrils in the brain is the most representative feature of neurodegenerative diseases. A detailed description of their structure and composition is essential to design new therapeutic approaches that allow patients to increase their life expectancy and quality of life. In Huntington’s disease (HD), the severity of the symptoms and the age of onset is strongly dependent on the number of glutamines above the threshold carried by the huntingtin protein of patients affected with this disorder. The two main objectives of this project are 1) to obtain atomic models of soluble and insoluble fibrils extracted directly from the brain tissues of individuals carrying extreme and moderate CAG repeats in the HTT gene and 2) mapping their in-situ interactions. Our approach will include state-of-the-art cryogenic electron microscopy, mass spectrometry-based proteomics and immunology. It will count on the participation of an interdisciplinary research group, comprising experts in HD pathology, structural biology and interactomics. The host institution counts with advanced facilities in image data analysis, cryo-EM and high-throughput proteomics that will be fully available. The host lab is an internationally recognised group that has more than 20 years of experience in carrying research focused on the molecular causes of HD in cell and animal models. It also has a strong background in mapping the interactions of the proteins that cause neurodegeneration in brain tissues. The host lab will take advantage of my expertise in assessing and validating protein-protein interactions through biochemical and biophysical methods. My visibility as a researcher will be greatly benefited by the extensive collaboration network of the host lab. The training and skills acquired during the execution of this project will expand and consolidate my research career and bring it to a very competitive point for taking a leading role as an independent researcher.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores