Twisted nanophotonic technology for integrated chiroptical sensing of drugs on a...
Twisted nanophotonic technology for integrated chiroptical sensing of drugs on a chip
The quest for new medical drugs demands reliable, ultrasensitive and fast techniques to identify, refine and test small volumes of candidates for clinical trials. The efficacy of pharmaceuticals depends to a large extent on their...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
PID2020-113081RB-I00
BIOMATERIALES EN NANOINGENIERIA: PRODUCCION Y APLICACIONES E...
169K€
Cerrado
RYC2021-034536-I
Nanomedicine strategies for diagnosis and treatment of vario...
236K€
Cerrado
Naturale-POC
Bridging the gap in nanoparticle based enzyme biosensing
166K€
Cerrado
EUIN2013-51165
DESARROLLO DE NUEVAS HERAMIENTAS DE DIAGNOSTICO PARA LA EVAL...
11K€
Cerrado
CanBioSe
Novel 1D photonic metal oxide nanostructures for early stage...
1M€
Cerrado
NANOCARB
Self selection of a multivalent nanosystem for carbohydrate...
180K€
Cerrado
Información proyecto TwistedNano
Duración del proyecto: 53 meses
Fecha Inicio: 2022-02-07
Fecha Fin: 2026-07-31
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
The quest for new medical drugs demands reliable, ultrasensitive and fast techniques to identify, refine and test small volumes of candidates for clinical trials. The efficacy of pharmaceuticals depends to a large extent on their chiral composition, and thus enantiomeric purity and selectivity is an important issue for the development of new drugs and to test their biotoxicity. TwistedNano addresses this need with a new generation of integrated nanophotonic devices enabling ultrasensitive chiroptical spectroscopy of sub-nanolitre volumes, revolutionizing at-source the sensing technological toolbox for drug discovery and nanomedicine.
Because of governmental regulations, agencies require pharmaceutical manufacturers to investigate systematically most of drug enantiomers to determine their safety/efficacy. Thus, the development of fast, compact and accurate chiral sensing on a chip is one of the current primary targets of the nanomedicine industry, constituting a growing market that is already exceeding 100 billion Euros. TwistedNano will result in a photonics-enabled chiral sensing technology that integrates vectorial structured light fields with almost arbitrary control onto a microfluidic chip, providing groundbreaking advantages compared to current instrumentation: (i) remote/distributed analysis, (ii) reduced sample consumption, (iii) cost reduction, (iv) parallelization, (v) increased diagnostic speed and sensitivity.
Key elements developed for optofluidic integration include photonic crystal fibers, photonic nanostructures, and metasurfaces operating in close synergy with cutting-edge chiroptical spectroscopic techniques. In the mid-term, TwistedNano will not only lay the foundations of a new lab-on-chip chiral sensing technology revolutionizing drug discovery, theranostics and nanomedicine, but also open a plethora of disruptive applications such as characterization of minute amounts of viruses and macromolecules in general.