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Twin4Promis

Financiado

Twinning for Excellence in Research, Training and Innovation in Protein Misfoldi...

Twinning for Excellence in Research, Training and Innovation in Protein Misfolding Diseases Protein misfolding diseases (PMDs) are a large group of human disorders caused by protein misfolding and include serious conditions with high socio-economic impact, such as Alzheimer’s disease, systemic amyloidosis, obesity, cysti... ver más

31/10/2025

NATIONAL HELLENIC...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

ETHNIKO IDRYMA EREVNON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 4 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-09-13

HORIZON-WIDERA-2021-ACCESS-03-01: Twinning Expected Outcome:To prevent further disparities, maximize investment in R&D and enhance economic...

Innovación

Cerrada hace 54 años

0% 100% 100%

4 Participantes

NATIONAL HELLENIC RESEARCH F...

602.50K€ | Lider

THE CHANCELLOR MASTERS AND S...

N.D. | Participante

UCPH

299.38K€ | Participante

VLAAMS INSTITUUT BIOTECHNOL...

299.50K€ | Participante

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Duración del proyecto: 37 meses Fecha Inicio: 2022-09-13
Fecha Fin: 2025-10-31

Líder del proyecto

ETHNIKO IDRYMA EREVNON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Protein misfolding diseases (PMDs) are a large group of human disorders caused by protein misfolding and include serious conditions with high socio-economic impact, such as Alzheimer’s disease, systemic amyloidosis, obesity, cystic fibrosis, retinitis pigmentosa and type 2 diabetes. The vast majority of them remain incurable so there is currently a great need for the development of effective therapeutics against them. Among the >70 known PMDs, about one third occur due to the misfolding of integral membrane proteins (MPs). MPs, however, are notoriously difficult to overexpress, isolate and study, both biochemically and structurally, thus constituting particularly challenging targets for therapeutic intervention with only few lead molecules in (pre)clinical pipelines. Furthermore, the scientific community involved in PMDs remains fragmented, with the majority of research targeting soluble proteins and only a small, rather isolated, sub-community focusing on misfolding-prone MPs. The National Hellenic Research Foundation has been exploiting the power of synthetic biology to develop efficient technologies targeting the misfolding of both soluble and membrane proteins. The coordinator wishes to build on these initial successes to partner with three prominent centers in PMD and synthetic biology research in order to establish a new excellence hub in research, training and innovation in PMDs and consolidate the scientific community in this field. Through this process, it will acquire a position among the leaders in the field of PMDs and converge with the most advanced institutions in terms of the quality of scientific data it produces, number of top-tier of scientific papers it publishes, amount of funding it secures from competitive sources, efficiency with which it trains its young scientists and contributes to their career development, the way it communicates the results of its research activity and converts them to tangible outcomes for high-tech entrepreneurship and the society.

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