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Trehalose as a source for privileged immunity in Drosophila

The immune response is an energy demanding process and immune cells must have a privileged access to energy/nutrients. While in mammalian system, this privileged access is achieved for example by insulin-independent glucose transp... ver más

12/02/2023

157K€

Presupuesto del proyecto: 157K€

Líder del proyecto

JIHOCESKA UNIVERZITA V CESKYCH BUDEJOVICICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-02-12

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

WF-01-2018: Widening Fellowships

I+D

Cerrada hace 6 años

0% 100%

2 Participantes

156.98K€ | Lider

ROYAL BERRIES

353.48K€ | Participante

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 38 meses Fecha Inicio: 2019-11-25
Fecha Fin: 2023-02-12

Líder del proyecto

JIHOCESKA UNIVERZITA V CESKYCH BUDEJOVICICH

TRL 4-5

Presupuesto del proyecto 157K€

Descripción del proyecto The immune response is an energy demanding process and immune cells must have a privileged access to energy/nutrients. While in mammalian system, this privileged access is achieved for example by insulin-independent glucose transporter, how is it achieved in insect is not known. The host laboratory has obtained preliminary results suggesting that the privileged access of fruit fly immune cells to nutrients might be achieved by using trehalose instead of glucose. It is known for a very long time that the primary sugar in insect is trehalose but it is a completely new idea that this carbohydrate could actually play an important role in the privileged access of immunity to resources, as in one of the most fundamental evolutionary trait. The goal of this project is therefore to test if activated Drosophila immune cells preferentially uptake trehalose and convert it to glucose intracellularly, being thus independent of the systemic carbohydrate regulation, and how important would it be for an efficient immune response. The project is based on a multidisciplinary approaches, when tissue-specific genetic tools will be used to manipulate metabolism in vivo in order to study immune response using techniques of molecular biology, developmental biology and immunology and state-of-the-art metabolic approaches. The goal for the researcher is to learn how to use Drosophila genetics and the infection models, well established in the host laboratory, and combine them with her expertise in insect physiology, cell culture and especially metabolomics.

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