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TRANSPOS-X

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Transposable elements their controllers and the genesis of human specific trans...
Transposable elements their controllers and the genesis of human specific transcriptional networks Transposable elements (TEs) account for more than two thirds of the human genome. They can inactivate genes, provide novel coding functions, sprinkle chromosomes with recombination-prone repetitive sequences, and modulate cellular... Transposable elements (TEs) account for more than two thirds of the human genome. They can inactivate genes, provide novel coding functions, sprinkle chromosomes with recombination-prone repetitive sequences, and modulate cellular gene expression through a wide variety of transcriptional and posttranscriptional influences. As a consequence, TEs are considered as essential motors of evolution yet they are occasionally associated with disease, causing about one hundred Mendelian disorders and possibly contributing to several human cancers. As expected for such genomic threats, TEs are subjected to tight epigenetic control imposed from the very first days of embryogenesis, in part owing to their recognition by sequence-specific RNA- and protein-based repressors. It is generally considered that the evolutionary selection of these TE controllers reflects a simple host-pathogen arms race, and that their action results in the early and permanent silencing of their targets. We have recently uncovered new evolutionary evidence and obtained genomic and functional data that invalidate this dual assumption, and suggest instead that transposable elements and their epigenetic controllers establish species-specific transcriptional networks that play critical roles in human development and physiology. The general objective of the present proposal is to explore the breadth of this phenomenon, to decipher its mechanisms, to unveil its functional implications, and to probe how this knowledge could be exploited for basic research, biotechnology and clinical medicine. ver más
31/12/2021
EPFL
3M€
Duración del proyecto: 60 meses Fecha Inicio: 2016-12-13
Fecha Fin: 2021-12-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2021-12-31
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-ADG-2015: ERC Advanced Grant
Cerrada hace 9 años
Presupuesto El presupuesto total del proyecto asciende a 3M€
Líder del proyecto
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5