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TRYP

Financiado

Transportable Hyperpolarization for Imaging

"Over the last five decades, Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) have become indispensable in analytical chemistry and medical diagnostics. Progress in high magnetic fields has elevated resolution... ver más

31/07/2025

UNIVERSITE LYON 1...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

UNIVERSITE LYON 1 CLAUDE BERNARD No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-01-29

ERC-2023-POC: ERC PROOF OF CONCEPT GRANTS Objective:Objectives:The ERC Proof of Concept Grants aim at facilitating exploration of the commerci...

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UNIVERSITE LYON 1 CLAUDE BER...

150.00K€ | Lider

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Duración del proyecto: 18 meses Fecha Inicio: 2024-01-29
Fecha Fin: 2025-07-31

Líder del proyecto

UNIVERSITE LYON 1 CLAUDE BERNARD No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Descripción del proyecto "Over the last five decades, Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) have become indispensable in analytical chemistry and medical diagnostics. Progress in high magnetic fields has elevated resolution and sensitivity, enabling faster data collection at minimal concentrations. However, the sensitivity of magnetic resonance has bounds. Hyperpolarization techniques, particularly Dissolution Dynamic Nuclear Polarization, are gaining attention for enhancing sensitivity. The downside is that hyperpolarization equipment is costly, operationally expensive, and technically challenging, hindering its widespread adoption in MRI facilities. A promising solution involves using transient photoexcited agents like triplets or photogenerated radicals. Our recent innovation leverages phase separation to extend hyperpolarization lifetimes of certain 13C-labelled targets to several hours. This facilitates the storage and transport of hyperpolarized molecules at 4.2 K. The upcoming TRYP validation will adapt this phase-separation approach to various samples, such as molecules and biological fluids, without using contaminating solvents. This method could democratize hyperpolarization benefits for the broader NMR and MRI communities. Specialized centers could produce and distribute hyperpolarized ""consumables"" that can be easily introduced into NMR or MRI systems. These matrices can polarize almost any water-based molecular solution for extended periods, enabling their long-distance transport to MRI centers, and can be easily filtered using conventional technologies."

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