Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles
BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechno...
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Información proyecto BRASINOEU
Líder del proyecto
UNIVERSITAET LEIPZIG
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
428K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of safe by design is based on the application of nanosafety to design the nanomaterials in order to prevent or reduce their possible harm to humans and the environment. The project encompass the synthesis of metal oxide NPs, with a focus on magnetic oxides, their surface modification and post modification in biological fluids; immunological and genotoxicity studies, and translocation studies both in vitro and in vivo. The project will seek to establish relationships between designed NP properties and their translocation at cellular and body level as well as their immune- and genotoxic response. This is a fundamental issue for the safe design of NPs. Also, the toxicological response will be studied as a function of the uptake dose of NPs. At cellular level a battery of techniques will be applied for localization and quantification of NPs: Transmission Electron Microscopy, Raman, Confocal Microscopy, Ion Beam Microscopy, etc. Positron Emission Tomography and Magnetic Resonance Imaging will be employed for biodistribution and quantification studies in animal models. BRASINOU is formed by an international team with the required and complementary expertise to address the proposed work from an international and multidisciplinary perspective. The project gathers internationally recognized groups in immunology, genotoxicity, nanoparticle synthesis, surface chemistry, biophysics, imaging and materials science. The complementary of the groups involved in the project will help to develop new highly skilled professional and scientific horizontal connections.