Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

TRAMLANES

Financiado

Cerrado

Transition metal lanthanide dyads for two photon cellular imaging

The proposed project is to use the combination of d-block and f-block units in the same dinuclear complex for parallel two-component luminescent imaging of different species in cells. This will rely on the unprecedented combinati... ver más

04/08/2015

USFD

231K€

Presupuesto del proyecto: 231K€

Líder del proyecto

THE UNIVERSITY OF SHEFFIELD No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-08-04 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

USFD

0.00€ | Lider

Proyectos interesantes

MRLI

Medical Technol...

Applied Physics

178K€ Cerrado

MAT2014-54395-P

Materials Scien...

Medical Technol...

70K€ Cerrado

MAT2017-83553-P

Materials Scien...

Electronics

73K€ Cerrado

LUCENT

Medical Technol...

Applied Physics

176K€ Cerrado

PID2021-122328OB-I00

Medical Technol...

Applied Physics

99K€ Cerrado

PID2020-114755GB-C31

Medical Technol...

Applied Physics

115K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

THE UNIVERSITY OF SHEFFIELD No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 231K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The proposed project is to use the combination of d-block and f-block units in the same dinuclear complex for parallel two-component luminescent imaging of different species in cells. This will rely on the unprecedented combination of two-photon excitation of a d-block luminophore (Pt- or Ir-based) having a long-lived excited state, followed by partial d-f energy-transfer to sensitise the lanthanide ion. This will generate two-component luminescence (blue, from the Ir/Pt unit; green or red, from the Tb or Eu unit, respectively) in which the two luminescence components have lifetimes that differ by three orders of magnitude (microsecond for d-block luminescence; millisecond for lanthanide luminescence). These different emission components can be selected at the detection stage using time gating such that purely one or the other, or a desired combination of both, can be detected in a given time window. In addition to providing two luminescence outputs with different colours and lifetimes, each luminescence component is independently sensitive to different species in cells and can therefore be used for imaging. The lifetime of Pt or Ir-based emission, from an 3MLCT excited state, is sensitive to quenchers such as dioxygen and variations in the luminescence lifetime in different parts of a cell can be used to visualise this. In contrast the relative intensity of Eu-based emission bands varies with the concentration of chelating anions such as citrate and hydrogen carbonate, allowing ratiometric intensity-based sensing of these species. Thus these d/f complexes will for the first time allow two different species to be imaged in real time using a single molecule under two-photon excitation conditions, which would constitute a major advance in the field with clear potential applications.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores