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Totipotency

Financiado

Transcriptional and Epigenetic Regulation of Totipotency in Mouse Early Embryos.

In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. It coincides with translation and degradation of maternally provided transcripts, initiation of... ver más

31/01/2022

FMI

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL R... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-01-31

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-ADG-2015: ERC Advanced Grant

I+D

Cerrada hace 9 años

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2 Participantes

FMI

2.86M€ | Lider

INDUSTRIAS EMILIO DIAZ,

470.24K€ | Participante

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Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 67 meses Fecha Inicio: 2016-06-27
Fecha Fin: 2022-01-31

Presupuesto del proyecto 3M€

Descripción del proyecto In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. It coincides with translation and degradation of maternally provided transcripts, initiation of global transcription called zygotic genome activation (ZGA), and epigenetic reprogramming of germline chromatin states into an embryonic state. The molecular mechanisms underlying this exquisite reprogramming of cell fate are barely understood. This research program has the ambitious goal to identify and characterize in a comprehensive way the transcription factors and chromatin regulators which initiate and regulate ZGA in a parental specific manner in early mouse embryos. We will utilize novel and highly sensitive genomic approaches to measure nascent transcription and determine open and modified chromatin landscapes in oocytes and early embryos, wild-type and conditionally deficient for major epigenetic modifiers. We will apply computational approaches to identify candidate TFs and histone modifiers controlling ZGA. We will use molecular and developmental biology approaches, combined with sensitive quantitative live-imaging, to interrogate the function of TFs and their binding sites for ZGA. We will further investigate the significance of possible paternal inheritance of nucleosomes at CpG islands for gene regulation during ZGA and later development by depleting nucleosomes from mature sperm by using sophisticated conditional deficiency and gain-of-function mouse models. By transferring nuclei of immature spermatid and mature sperm into oocytes, we will interrogate the relevance of nucleosome eviction during spermatogenesis, as a possibly truly epigenetic reprogramming process, for defining embryonic competence. ERC funding would represent a crucial contribution to dissecting the molecular mechanisms underlying acquisition of totipotency in mouse embryos and may impact on the use of Assisted Reproductive Technologies in human med

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