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Tracking adaptation of naïve T cells to distinct organs to decode organ-specifi...

Tracking adaptation of naïve T cells to distinct organs to decode organ-specific immune diseases Organ-specific immune-mediated inflammatory diseases (IMIDs) have a growing socio-economic impact due to their steadily increasing incidence. At least two aspects are still unclear: what immunological mechanisms restrict these dis... ver más

31/03/2029

UKE

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITAETSKLINIKUM HAMBURGEPPENDORF No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-12-13

ERC-2023-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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1 Participantes

UKE

2.00M€ | Lider

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Duración del proyecto: 63 meses Fecha Inicio: 2023-12-13
Fecha Fin: 2029-03-31

Líder del proyecto

UNIVERSITAETSKLINIKUM HAMBURGEPPENDORF No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Organ-specific immune-mediated inflammatory diseases (IMIDs) have a growing socio-economic impact due to their steadily increasing incidence. At least two aspects are still unclear: what immunological mechanisms restrict these diseases to one or a set of specific organs and what triggers the continuously increasing incidence, particularly in industrialized countries. Increasing exposure to harmful environmental triggers, such as pollution but also Western diet, have been suggested as potential reasons. We propose that when locally active immune cells are perturbed by harmful environmental triggers this leads to organ-specific IMIDs. Naïve CD4+ T cells have so far been considered a quasi-homogenous and inert population excluded from organs. Therefore, their contribution to organ-specific IMIDs has been overlooked. Contrary to this, there is evidence that naïve T cells circulate through organs and diversify into different subpopulations reflecting the organ they patrol. This project aims to reveal whether organ adaptation of naïve T cells in steady state is one of the key mechanisms contributing to the organization of the immune system into districts of competence - i.e., areas of inflammation. We also aim to understand whether organ-specific naïve T cells responding to harmful environmental triggers set the early premise for the development of organ-specific IMIDs. We will study this using a unique portfolio of healthy and diseased human organs in combination with multi-modal single-cell technologies to gain an unprecedented resolution in the analysis of naïve T cells. Next, we will use mouse models and 3D human cocultures to test naïve T cell function and response to environmental triggers. This project will influence the current understanding of how the activity of the immune system is adapted and distributed throughout the body, which will also push the boundary of precision medicine to consider organ-specific naïve T cells when designing future immunotherapies.

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