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AUTO NERVE

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Tracers for targeting nerves in the autonomic nervous system

"""As a common disease in western men, prostate cancer is a major driver for the billion-euro robotic surgery and laparoscopic devices markets. In the surgical management of prostate cancer patients, next to the tumor resection ac... see more

29/02/2020

Leiden University...

140K€

Project Budget: 140K€

Project leader

ACADEMISCH ZIEKENHUIS LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-02-29

ERC-2017-PoC: ERC-Proof of Concept Scope:Scope:

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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2 Participantes

Leiden University Medical Ce...

140.00K€ | Leader

SIMON, SA

1.02M€ | participant

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Project duration: 20 months Date Start: 2018-06-13
End date: 2020-02-29

Project leader

ACADEMISCH ZIEKENHUIS LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 140K€

participation deadline Sin fecha límite de participación.

Project description """As a common disease in western men, prostate cancer is a major driver for the billion-euro robotic surgery and laparoscopic devices markets. In the surgical management of prostate cancer patients, next to the tumor resection accuracy, the surgeon’s ability to preserve the nerve-network and prevent erectile dysfunction and urinary incontinence, is key. As these nerves are not visible by eye, image guided surgery approaches aimed at nerve-sparing demand the clinical availability of nerve-specific fluorescence tracers. Hereby it is expected that the ability to visualize peripheral nerves promotes nerve-sparing opportunities and opens up new commercial-avenues for companies involved in the surgical market. Previously my ILLUMINATING NERVES ERC-StG yielded a sensory-nerve targeted lead-compound that was made suitable for imaging somatic-nerves (MY NERVE ERC-PoC). This tracer, however, does not allow for imaging of the autonomic nerves. For autonomic nerves I have now shown, within the same ERC-StG, that an alternative tracer can be used as an imaging target. The aim of the AUTO NERVE ERC-PoC project is to convert the autonomic-nerve targeted lead-compound into a fluorescence tracer. Systematic fine-tuning of this lead will optimize the structure-activity relation and will improve the chance of future commercialization. Ultimately, the outcome of the three complementary ERC-grants should yield an advancement in clinical care."

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