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Towards clinical trials for a novel treatment for stroke

Stroke is the leading cause of adult disability and represents a major health problem in the EU and the Western world. Despite available acute care treatment and rehabilitation therapies, more than half of the patients remain disa... ver más

31/08/2018

UZH

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-08-31

ERC-PoC-2016: ERC-Proof of Concept-2016

I+D

Cerrada hace 8 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UZH

150.00K€ | Lider

OCTOPUS SERVICIOS DE PRODUCC...

150.90K€ | Participante

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Duración del proyecto: 20 meses Fecha Inicio: 2016-12-19
Fecha Fin: 2018-08-31

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Stroke is the leading cause of adult disability and represents a major health problem in the EU and the Western world. Despite available acute care treatment and rehabilitation therapies, more than half of the patients remain disabled and there is a large unmet medical need accordingly. Regeneration of interrupted nerve fiber tracts and plastic hardware changes in the adult mammalian central nervous system are extremely restricted, a phenomenon which represents a key reason for the low degree of recovery following CNS injuries including stroke. The molecular impediments that form the basis of this phenomenon are neurite growth inhibitory proteins expressed in central nervous system myelin, in particular the membrane protein Nogo-A which was discovered by our group. Importantly, antibodies directed against Nogo-A have been shown to induce axonal regeneration, enhance plastic circuit rearrangements and mediate significant improvements in functional recovery in rodent and non-human primate models of stroke and spinal cord injury. As recently shown in the ERC advanced grant supported the project ‘Nogorise’, almost full functional recovery was observed in rats with large strokes when anti-Nogo-A antibody treatment was followed by intensive rehabilitative training. As currently no therapy for human stroke patients beyond acute care and rehabilitation exists, there is a substantial market opportunity for the anti- Nogo-A therapy. The proposed activities within the present project aim at further establishing preclinical proof-of-concept for an anti-Nogo-A administration paradigm translatable to human stroke patients and development of human antibodies targeting Nogo-A. The expected data package will allow the critical transition from preclinical to clinical development and support the development of a comprehensive business strategy.

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