Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

TissueLymphoContexts

Financiado

Tissue resident Lymphocytes Development and Function in real life Contexts

Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to micr... ver más

30/06/2024

UNI WUERZBURG

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

JULIUSMAXIMILIANSUNIVERSITAT WURZBURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-06-30

ERC-2017-STG: ERC Starting Grant

I+D

Cerrada hace 8 años

0% 100% 100%

2 Participantes

UNI WUERZBURG

1.50M€ | Lider

LACTEOS DE NAVARRA

269.37K€ | Participante

Últimas noticias

02-12-2024: AGENCIA-VALENCIANA-D... En las últimas 48 horas el Organismo AGENCIA VALENCIANA D... ha otorgado 1 concesiones

02-12-2024: CDTI En las últimas 48 horas el Organismo CDTI ha otorgado 4 concesiones

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

Duración del proyecto: 79 meses Fecha Inicio: 2017-11-27
Fecha Fin: 2024-06-30

Líder del proyecto

JULIUSMAXIMILIANSUNIVERSITAT WURZBURG

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to microbial invasion. In addition to immediate effector functions, tissue-resident lymphocytes orchestrate and regulate inflammatory responses, and contribute to tissue homeostasis, repair and barrier function. Understanding the generation and function of tissue-resident lymphocytes is therefore expected to reveal targets for improving vaccination and immunotherapy. Barrier tissues of free-living mice and men, but not those of laboratory mice kept under specific pathogen free conditions, are continuously exposed to an array of antigenically complex pathogens, microbial symbionts and environmental factors, which dramatically alter the abundance, composition and basal activation state of local pools of tissue-resident cells. Therefore, we propose to study the development, functions and cellular interactions of tissue-resident lymphocytes in experimental models that mirror real-life contexts. First, we will investigate how polyclonal pools of tissue-resident memory CD8+ T cells (TRMs) are established during infection with antigenically complex pathogens. Second, we will restore physiologic exposure to specific pathogens and induce alterations of local microbiota in SPF mice, in order to investigate the induction, function and local interactions of tissue-resident lymphocytes in physiologic tissue environments. In addition, we will explore targeted microbial exposure as a „vaccination strategy to induce „non-canonical tissue-resident cells in the lung in order to improve protection against infections with multi-resistant bacteria representing major clinical problems in hospitalized patients. In summary, we will investigate fundamental mechanisms of tissue immunity and vaccination in contexts relevant for human physiology and disease.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores