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LOMAIVITICINS

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THE SYNTHESIS OF DIAZOBENZOFLUORENE ANTITUMOR ANTIBIOTICS LOMAIVITICINS...

THE SYNTHESIS OF DIAZOBENZOFLUORENE ANTITUMOR ANTIBIOTICS LOMAIVITICINS A B AND KINAMYCIN C The proposed research describes a strategy for the convergent synthesis of diazobenzofluorene containing antitumor antibiotics Lomaiviticins A and B as well as the structurally related Kinamycin C. They are potent DNA cleaving ag... ver más

31/08/2012

UOI RESEARCHCOMMIT...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

PANEPISTIMIO IOANNINON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-08-31 No tenemos la información de la convocatoria

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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1 Participantes

UOI RESEARCHCOMMITTEE

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Líder del proyecto

PANEPISTIMIO IOANNINON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The proposed research describes a strategy for the convergent synthesis of diazobenzofluorene containing antitumor antibiotics Lomaiviticins A and B as well as the structurally related Kinamycin C. They are potent DNA cleaving agents and exhibit remarkable activity against a broad spectrum of cancer cell lines. These structurally novel antitumor antibiotics have a unique cytotoxicity profile, compared to other known DNA-damaging anticancer drugs such as adriamycin and mitomycin C, which may suggest a different mechanism of interaction with DNA. However, the currently limited availability of these compounds isolated by fermentation and the present lack of any methodology to generate synthetic analogs could hamper further research in the analysis of these highly potent DNA-cleaving agents. Access to these natural products as well as their analogs by means of chemical synthesis, would enable the scientific community to elucidate their mode of action and the origin of their cytotoxicity. Thus, in the absence of an alternative state of the art and given the potential of these molecules to become therapeutic cancer agents, the main objectives of the proposed project are: a) the development of a synthetic methodology for the convergent synthesis of lomaiviticins and their analogs, b) extension of this methodology towards the synthesis of the structurally related antitumor antibiotic kinamycin C, and c) the design and synthesis of structurally diverse diazobenzo[a]fluorene analogs aiming to identify new cytotoxic agents and some of the structural features required for their biological activity.

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