PomXYZ
Financiado
The PomXYZ cluster in the bacterium Myxococcus xanthus: Self-assembly, transloca...
The PomXYZ cluster in the bacterium Myxococcus xanthus: Self-assembly, translocation, and fission of an active protein complex that guides cell division
In my research project I will theoretically model a fundamental process in the cell division of the model bacterium Myxococcus xanthus, namely the process for guiding the machinery for cell division to midcell. In M. xanthus, a cl...
In my research project I will theoretically model a fundamental process in the cell division of the model bacterium Myxococcus xanthus, namely the process for guiding the machinery for cell division to midcell. In M. xanthus, a cluster comprised of the proteins PomX, PomY, PomZ self-assembles on the nucleoid surface and in an ATP-consuming reaction cycle translocates to midcell, to guide the cell division machinery there. During cell division the Pom cluster undergoes fission, and the resulting two Pom clusters on the daughter cells again translocate to the respective midcell to induce further cell divisions. I will consider a mesoscopic model which combines spatial dynamics with locally stimulated reactions, to study the formation, translocation, and fission of the Pom cluster. My model is informed, and will be further refined, using experimental results of the group of Lotte Søgaard-Andersen at the MPI for Terrestrial Microbiology, an established collaborator of my supervisor Erwin Frey. I will quantify the constraints imposed on the protein-protein and protein-nucleoid interactions by the tasks the Pom cluster needs to fulfill (self-assembly, translocation, fission), and relate my mesoscopic model both to previously proposed heuristic models on Pom cluster translocation and to (stochastic) reaction-diffusion models. My project will lead to a deeper understanding of how biological systems actively create and maintain order. My mesoscopic model combines spatial dynamics with locally stimulated reactions, which are the two conceptual building blocks needed for spatial organization driven by energy consumption. My model will therefore be applicable also in other instances of biological self-organization, as well as in self-assembly of artificial nanostructures, both of which are active and growing research directions. My project will therefore make my research profile more impactful, which will help me to reach my goal of becoming an independent group leader.
ver más
Duración del proyecto: 26 meses
Fecha Inicio: 2022-07-04
Fecha Fin: 2024-09-30
Fecha Fin: 2024-09-30
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-09-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2021-PF-01-01:
MSCA Postdoctoral Fellowships 2021
Cerrada
hace 3 años
Presupuesto
El presupuesto total del proyecto asciende a
190K€
Líder del proyecto
LUDWIGMAXIMILIANSUNIVERSITAET MUENCHEN
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5