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STRESSEDASTROCYTES

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The interplay between astrocytes and neurons in the progression of stress induce...

The interplay between astrocytes and neurons in the progression of stress induced cognitive disorders "Stress exposure sets primarily a response to restore physiological homeostasis and promote behavioural adaptation. However, prolonged stressful experience may trigger maladaptive responses that lead to severe manifestations such... ver más

29/12/2014

UMINHO

153K€

Presupuesto del proyecto: 153K€

Líder del proyecto

UNIVERSIDADE DO MINHO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-12-29 No tenemos la información de la convocatoria

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1 Participantes

UMINHO

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Líder del proyecto

UNIVERSIDADE DO MINHO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 153K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Stress exposure sets primarily a response to restore physiological homeostasis and promote behavioural adaptation. However, prolonged stressful experience may trigger maladaptive responses that lead to severe manifestations such as depressive-like behaviour, learning and memory deficits. Indeed, advances in neurobiology reported clear morphological deficits in neurons of both hippocampus and prefrontal cortex (PFC) after chronic-stress exposure. However, the classical paradigm that brain information processing is exclusively a neuronal process has been challenged by an emerging body of evidence. In fact, there is a lack of information regarding stress effects on glial cells, whose importance is rising due to exciting data supporting dynamic neuron-glia interactions. Blockade of neurotransmitter release from astrocytes in vivo contributed to unexpected behaviour modulation, namely affecting sleep control. Moreover, ex vivo immunohistochemistry pointed out astrocytic loss in regions affected by stress exposure. In light of these thrilling observations, it is predictable that astrocyte function may be implicated in stress-induced cognitive impairments. Therefore, we propose here the multidisciplinary and innovative dissection of the astrocytic contribution to the progression of stress-related cognitive disorders across the PFC and hippocampus by: (1) assessing the extent of the stress-induced effects, through a battery of behaviour tests for cognitive and depressive-like behaviour, after conditioned genetic or pharmacological blockade of astrocytic function; (2) combining three complementary electrophysiological in vivo techniques and producing a thorough characterization of the astrocytic contribution to stress-induced changes throughout time; and (3) associating ex vivo patch-clamp recordings and a comprehensive immunohistochemical analysis to reveal specific morphological implications in the disorder progression, both in neurons and astrocytes."

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