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Island in the brain

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The impact of cues and negative consequences on decision making the role of the...

The impact of cues and negative consequences on decision making the role of the insular cortex Psychiatric disorders such as addiction, depression and anxiety disorder are characterized by suboptimal decision making (DM) due to aberrant processing of negative information. However, it remains unclear which brain processes un... ver más

31/03/2023

188K€

Presupuesto del proyecto: 188K€

Líder del proyecto

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-03-31

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

187.57K€ | Lider

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Duración del proyecto: 35 meses Fecha Inicio: 2020-04-09
Fecha Fin: 2023-03-31

Líder del proyecto

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 188K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Psychiatric disorders such as addiction, depression and anxiety disorder are characterized by suboptimal decision making (DM) due to aberrant processing of negative information. However, it remains unclear which brain processes underlie suboptimal DM. One candidate brain region involved is the insular cortex (insula), which has been implicated in DM and in several psychiatric disorders. Laboratory tasks to assess DM in humans closely mimic real-life situations, providing participants with cues to guide their decisions, which can lead to winning or losing money, much like weighting information about risks and benefits when choosing between investing in stocks or bonds. However, the technology available to study the human brain is limited, whereas experiments with rodents allow for a detailed and fine-grained understanding of brain function. Importantly, in order to translate results between rodents and humans, the tasks used to assess behaviour need to be comparable, but there are currently no tasks in rodents to study cue-guided DM in the face of punishment. During the fellowship, I will study the involvement of the insula in DM when using cues to inform rats about potential punishments and benefits. To achieve this, I will: 1) Develop a novel behavioural task to assess cue-guided risk/punishment decision making in rats. 2) Assess the contribution of the insula by perturbing neural signalling in this brain region, and the network it is embedded in. The novel task has tremendous translational value in that it parallels tasks used in human populations and mimics real-life decisions. Therefore, the results of the project are relevant for testing the efficacy of treatment strategies targeted at the insula to alleviate psychiatric disorders such as anxiety disorders and addiction.

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