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HYGIENE

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THE HYGIENE HYPOTHESIS REVISITING THE CONCEPT BY INTEGRATING EPIDEMIOLOGY AND...

THE HYGIENE HYPOTHESIS REVISITING THE CONCEPT BY INTEGRATING EPIDEMIOLOGY AND MECHANISTIC STUDIES The hygiene hypothesis postulating the paradoxical protective role of infections on immune-mediated diseases including atopy (i.e. atopic dermatitis, rhinitis, asthma) and more recently autoimmune diseases has been the matter of e... ver más

31/07/2015

INSERM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-07-31 No tenemos la información de la convocatoria

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2 Participantes

INSERM

0.00€ | Lider

IRFMN

N.D. | Participante

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Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The hygiene hypothesis postulating the paradoxical protective role of infections on immune-mediated diseases including atopy (i.e. atopic dermatitis, rhinitis, asthma) and more recently autoimmune diseases has been the matter of extensive investigation. The aim of the present project is to validate this hypothesis integrating epidemiological and experimental studies. We will review in a meta-analysis published studies of direct and indirect markers of infections and atopic diseases, and conduct a case-control study to analyse the association between infections and atopy using atopic dermatitis as a prototypic model. This epidemiological study will assess the occurrence of different infections and other risk factors related to the incidence of atopic dermatitis in children under age five in Italy (300 cases and 600 controls). This epidemiological study will be supported by experimental approaches addressing mechanistic questions raised by the hygiene hypothesis. Experimental models will include induction of acute and chronic bronchoconstriction/asthma, atopic dermatitis. In addition the project will aim at devising new mouse models of atopy. The nature of infections providing protection against allergic diseases will be investigated to characterise the difference at the molecular level between protective and non protective pathogens or their derivatives. The underlying immune mechanisms notably homeostasis imbalance, antigenic competition, stimulation of regulatory immune cells and Toll-like receptor involvement will be analysed. In addition to developing integrated in vivo models, including the use of transgenic animals, efforts will be focussed on the study of available synthetic pathogen-derived compounds showing a protective activity to better approach their cellular and molecular mode of action. These studies may pave the way to novel and safe therapies that could advantageously substitute for the protective immune stimulation induced by major infections.

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