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Aqua-Synapse

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The health benefits of deuterium depletion on synaptic function, regional metabo...

The health benefits of deuterium depletion on synaptic function, regional metabolism, and behaviour Core idea of this project is to establish the mechanistic basis for the positive health effects of deuterium depleted water and determine what regimens are most efficacious. Isotope content of drinking water has been shown affect... ver más

31/12/2026

ULusofona

Presupuesto desconocido

Líder del proyecto

COFAC COOPERATIVA DE FORMACAO E ANIMACAO CULT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-01-01

HORIZON-MSCA-2021-SE-01-01: MSCA Staff Exchanges 2021 Expected Outcome:

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ULusofona

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Duración del proyecto: 47 meses Fecha Inicio: 2023-01-01
Fecha Fin: 2026-12-31

Líder del proyecto

COFAC COOPERATIVA DE FORMACAO E ANIMACAO CULT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Core idea of this project is to establish the mechanistic basis for the positive health effects of deuterium depleted water and determine what regimens are most efficacious. Isotope content of drinking water has been shown affect the pathogenesis of cancers to ameliorate the stress response and reduce susceptibility to many diseases, but it remains unclear how the positive biological effects of heavy isotope reduction in drinking water are mediated. High concentrations of deuterium induce mitochondrial dysfunction, and very high concentrations can induce cell death, but the administration of deuterium at 91 ppm has antidepressant effects that were comparable to that of citalopram in a mouse model of depression. Use of deuterium depleted water appears to represent a safe intervention with few, if any, reported side effects, but it remains unclear at what concentrations the positive metabolic and behavioral effects become apparent. Companies in Europe now sell DDW at different concentrations to the public amidst a plethora of health claims that mostly lack in any sound scientific basis or safety data Thus, there is an urgent need to better understand the impact of DDW on brain and behavior at a molecular level. We will use state-of-the art imaging techniques to measure regional metabolic fluxes in the body of animals in healthy individuals throughout life and those subject to stress following the administration of DDW at different concentrations and for different periods. Also we examine how deuterium depletion affects the behaviors of neurons in vitro and electrophysiological levels and in terms of their metabolism. The project is made possible by bringing together a consortium of chemists, cell biologists, pharmacologists, imaging specialists, psychiatrists, and DDW producers for ‘medicinal needs’ in fully translational work packages to discover, in an empiric manner, how the manipulation of metabolic pathways with DDW can be employed for the benefit of human health

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