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ParadOX

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The hardships for life to become big rethinking hypoxia as an evolutionary dr...

The hardships for life to become big rethinking hypoxia as an evolutionary driver for the rise of complex multicellularity Why complex life evolved on Earth has puzzled scientists for as long as sufficient oxygen has been deemed vital. Motivated by recent discoveries, however, this project will investigate the dawning paradox that multicellular life r... see more

31/12/2025

LUNDS UNIVERSITET

2M€

Project Budget: 2M€

Project leader

LUNDS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-09-08

ERC-2020-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada does 5 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

LUNDS UNIVERSITET

1.50M€ | Leader

GUARDIAN LLODIO UNO

628.01K€ | participant

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Project duration: 63 months Date Start: 2020-09-08
End date: 2025-12-31

Project leader

LUNDS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description Why complex life evolved on Earth has puzzled scientists for as long as sufficient oxygen has been deemed vital. Motivated by recent discoveries, however, this project will investigate the dawning paradox that multicellular life requires low oxygen (hypoxia) internally to thrive in the oxic niche. Central biological mechanisms in animals and plants need protection from oxygen and appears to depend on hypoxic niches. I have previously reconciled geological and medical observations to demonstrate how biological innovation to harness hypoxia would have allowed animals to conquer the previously inaccessible oxic niche. Although life must have invented several solutions to the paradox, the only known is the recent Nobel Prize-awarded mechanism of how cells sense oxygen. Earth history can uniquely evaluate its evolutionary importance through a geologic lens. In ParadOX, I propose to build a transdisciplinary team that provides a novel geobiological evaluation of the role of innovations that harness hypoxia and the processes that led to them. ParadOX will: 1) Experimentally define a) Paleozoic oxygenation as kill-mechanism for species with limited access to hypoxia b) Role of hypoxia for invertebrate longevity and life cycle 2) Theoretically explore a) Changes in Neoproterozoic shelf area and daily O2 fluctuations as drivers of hypoxia-machineries b) Co-evolution of hypoxia-machineries in animals and plants The project uniquely integrates knowledge from geology, biology, medicine, and numerical modeling. ParadOX’s inquiries groundbreakingly shift our perspective from a simplistic to a dualistic view on the role of oxygen for complex life. Insight to the evolutionary importance and processes that underpin biological innovations to harness hypoxia will advance our view on the rise of multicellularity on Earth, on other planets, and even within us as tumor multicellularity. ParadOX opens a new horizon of investigations into the drivers and the hardships of complex life.

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