Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

CARDIOCALC

Financiado

The fundamentals of cardiovascular calcification: from cells to therapy

With this project I propose to identify fundamental mechanisms of cardiovascular calcification (CVC) and new therapeutic targets using zebrafish as a model system. CVC, characterised by progressive calcification of the soft tissue... ver más

30/09/2027

INSERM

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-04-26

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2021-STG: ERC STARTING GRANTS

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

INSERM

1.21M€ | Lider

Proyectos interesantes

EUIN2015-62897 PREPARACION DE PROPUESTA PARA EUROPEAN INDUSTRIAL DOCTORATE... 25K€ Cerrado

PID2019-111456RB-I00 DESREGULACION DE LA SEÑALIZACION DE CALCIO EN ENFERMEDADES C... 84K€ Cerrado

PTQ-17-09369 Identificación de terapias innovadoras contra cardiomiopatía... 104K€ Cerrado

SAF2013-48210-C2-1-R ANALISIS IN VITRO E IN VIVO DE LA FUNCION DE C3G EN DIFERENT... 133K€ Cerrado

JCI-2011-09663 Vascular calcification and atherosclerosis: Molecular mechan... 96K€ Cerrado

3DCardiacHTS Bringing 3D cardiac tissues to high throughput for drug disc... 1M€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 65 meses Fecha Inicio: 2022-04-26
Fecha Fin: 2027-09-30

Presupuesto del proyecto 1M€

Descripción del proyecto With this project I propose to identify fundamental mechanisms of cardiovascular calcification (CVC) and new therapeutic targets using zebrafish as a model system. CVC, characterised by progressive calcification of the soft tissue causing impaired blood circulation, is a frequent form of cardiovascular disease. Because the pathophysiology of CVC is highly heterogeneous, the exact cell types and signalling pathways triggering tissue calcification are still unknown, thus limiting therapy options. Most studies on CVC rely on in vitro systems, which fail to reproduce the multicellular environment, or mammalian in vivo models, limited for live-imaging and high-throughput analyses. By combining my expertise in cardiovascular research and bone biology, I propose to use zebrafish as a model to elucidate the multifactorial mechanisms of CVC, focusing on different developmental stages and cardiovascular tissues. In Aim 1, I will use a broad array of zebrafish genetic models to characterise the cellular dynamics, molecular mechanisms and functional impact of CVC in vivo. I will also study the role of specific cell populations present in regenerating valves and human valve implants with CVC. In Aim 2, I propose to identify new local and systemic therapeutic strategies to block/reverse CVC, taking advantage of the zebrafish amenability for genetic manipulation and high-throughput screening. I will recruit bone-degrading cells to the CVC site and determine their potential to reverse tissue calcification. Moreover, I will select a short list of small molecules identified in a large-scale screen in zebrafish and will test their therapeutic potential in cardiovascular cells derived from hiPSCs of CVC patients. Altogether, with this interdisciplinary approach, I expect to bring a new perspective on the mechanisms and therapeutic targets to block/reverse CVC, which could have a considerable impact on the European population, severely affected by these diseases.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores