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The Fluctuating Enzyme From Catalysis to Vibrational Dynamics

Enzymes spin the wheel of life by catalyzing a myriad of chemical reactions central to the growth, development, and metabolism of all living organisms. Without enzymes, essential processes would progress so slowly that life would... ver más

31/07/2026

TAU

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

TEL AVIV UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-08-20

ERC-2020-STG: ERC STARTING GRANTS

I+D

Cerrada hace 5 años

0% 100% 100%

2 Participantes

TAU

1.50M€ | Lider

LA FARGA LACAMBRA

1.01M€ | Participante

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Duración del proyecto: 71 meses Fecha Inicio: 2020-08-20
Fecha Fin: 2026-07-31

Líder del proyecto

TEL AVIV UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Enzymes spin the wheel of life by catalyzing a myriad of chemical reactions central to the growth, development, and metabolism of all living organisms. Without enzymes, essential processes would progress so slowly that life would virtually grind to a halt, and the quest to determine their inner workings thus continues to attract and fascinate scientists over a broad range of disciplines. Cutting-edge methods now allow one to observe and manipulate individual enzymes in their reaction course. These revealed that chemistry at the single-molecule level is inherently stochastic and, at times, extremely unintuitive. Thermal fluctuations push enzymes to vibrate erratically and force a probabilistic description, but classical approaches are deeply entrenched in determinism, and so is our basic expectation for how things should behave in the world around us. The groundbreaking purpose of this proposal is to bring advanced theoretical methods and mathematical tools to the analysis of stochastic fluctuations of enzymes and proteins at the single-molecule level. These will be based on state-of-the-art approaches in statistical physics and stochastic processes that I will adapt and further advance to need. Equipped with mathematical techniques that have so far been foreign to the field, I expect to rectify fundamental flaws in our understanding, predict the emergence of novel phenomena, and show how single-molecule fluctuations can be extracted from bulk, steady-state, concentrations—despite belief that this is fundamentally impossible. Novel analysis methods that I will apply to tens of thousands of protein structures would complement these efforts and aid in the discovery of unifying principles governing thermal fluctuations of enzymes and proteins. The amalgamation of all these efforts will pave the way to large-scale, multi-tier, characterization of fluctuations which is expected to transform our understanding of enzymes and enzymatic catalysis.

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