EvoComBac
Financiado
The evolutionary epidemiology of commensal bacteria the case of Escherichia col...
The evolutionary epidemiology of commensal bacteria the case of Escherichia coli from 1980 to 2025
Understanding the rapid adaptation of infectious pathogens is crucial to design better management policies and anticipate future changes. Yet, existing models often fail to explain these dynamics. I will address this major challen...
Understanding the rapid adaptation of infectious pathogens is crucial to design better management policies and anticipate future changes. Yet, existing models often fail to explain these dynamics. I will address this major challenge of evolutionary biology in the bacterial species Escherichia coli. E. coli is a commensal of the human gut and an opportunistic pathogen causing infections responsible for more than a million deaths worldwide per year. E. coli has rapidly evolved over the last four decades. From the 1980s, starting from an almost fully sensitive population, multiple antibiotic resistances have emerged and stabilised at an intermediate frequency. Concomitantly, virulence, the propensity to cause infections, increased. The evolutionary processes causing these changes are largely unknown. To elucidate the drivers of the evolution of commensal E. coli, I will develop a prospective cohort of 200 longitudinally followed healthy volunteers—the largest cohort of its kind. We will analyse these data in the light of an integrative statistical and mathematical framework describing the ecology of E. coli from the within-host to the population level. These models will generate testable predictions on the evolution of genomic variants determining virulence, resistance, and colonisation ability. These predictions will be validated on an exceptional existing dataset composed of 1000 bacterial genomes sampled from healthy human hosts from 1980 to 2025 encompassing around 100,000 generations of bacterial evolution. This original interdisciplinary framework draws from epidemiology, evolutionary biology and genomics for a better understanding of the evolution of bacteria. This project is a step towards better predictions of evolutionary dynamics and better stewardship policies for infectious pathogens.
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Duración del proyecto: 65 meses
Fecha Inicio: 2020-12-15
Fecha Fin: 2026-05-31
Fecha Fin: 2026-05-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2020-12-15
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2020-STG:
ERC STARTING GRANTS
Cerrada
hace 5 años
Presupuesto
El presupuesto total del proyecto asciende a
1M€
Líder del proyecto
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
3.30M€ |
Participante