Innovating Works

EvolvingCircuits

Financiado
The evolution of neural circuits for navigational decisions - from synapses to b...
Of the 1.2 million animal species described on Earth, more than 80% are insects. As for mammals, each insect is equipped with a brain that has evolved to optimally control the species’ behavior in the context of its environment. I... Of the 1.2 million animal species described on Earth, more than 80% are insects. As for mammals, each insect is equipped with a brain that has evolved to optimally control the species’ behavior in the context of its environment. In more than 450 million years of evolution the neural circuits guiding behavioral decisions have diverged from an ancestral version to enable insects to conquer every terrestrial habitat on the planet and to equip many species with behavioral strategies that rival even mammals in complexity. These circuits thus have to be rigid enough to maintain their ancestral, core functions, while also being sufficiently adaptable to enable the addition of novel functions. The mechanisms of how this is achieved across vast evolutionary timescales are unknown. While this is true for all animals, insects with their numerically simpler brains and a comparably rigid neuroarchitecture offer the unique chance to unravel the evolution of decision making circuits at the level of identified neurons and synapses. Aided by recent technological breakthroughs and the establishment of rich ground-truth data in the fruit fly, I will combine whole brain anatomy, connectomics and computational modeling with electrophysiology and behavior to dissect the evolution of the central decision making center of insect brains, the central complex - across the entire insect phylogeny. I aim to reveal how this region has evolved in the context of the entire brain, how its intrinsic circuits have changed with increasing evolutionary distance (circuit phylogeny), and which changes in its circuitry are linked to specialized behavioral abilities (circuit adaptation). Finally, I will directly establish behavioral correlates of identified circuit features (circuit function), attaching relevance to connectomics data in a way that is achievable only by a wide, comparative approach - raising our understanding of structure-function relations in animal nervous systems to a new level. ver más
31/08/2027
LUNDS UNIVERSITET
2M€
Perfil tecnológico estimado
Duración del proyecto: 65 meses Fecha Inicio: 2022-03-29
Fecha Fin: 2027-08-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-03-29
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2021-COG: ERC CONSOLIDATOR GRANTS
Cerrada hace 3 años
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
LUNDS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5