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EVOMENS

Financiado

The evolution of menstruation in primates

Menstruation is a recent evolutionary innovation in primates: the trait is present in some species (humans, baboons) but not in closely related others (orangutans, vervets). In the latter and in most mammals, the uterine endometri... ver más

30/06/2025

INSERM

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-12-19

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

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2 Participantes

INSERM

1.19M€ | Lider

GLUAL HIDRAULICA

346.91K€ | Participante

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 66 meses Fecha Inicio: 2019-12-19
Fecha Fin: 2025-06-30

Presupuesto del proyecto 1M€

Descripción del proyecto Menstruation is a recent evolutionary innovation in primates: the trait is present in some species (humans, baboons) but not in closely related others (orangutans, vervets). In the latter and in most mammals, the uterine endometrium is reabsorbed at the end of the cycle instead of being shed when fecundation has not occurred. The molecular and genetic underpinnings of this complex process are not fully understood, despite its critical involvement in gynaecological conditions. I propose to discover the molecular mechanisms leading to menstruation by comparing the uterine linings from five primate species at the cellular, functional and genetic levels. The objectives are to identify the gene networks and non-coding regulatory elements that control the advent of menstruation in primates, and to understand how this genetically inherited trait was acquired in primate genomes during the evolution of the human lineage. In Aim 1, I will leverage single-cell transcriptomics to uncover the cellular composition and marker modifications that differentiate the uterine linings of menstruating and non-menstruating primates. In Aim 2, I will use deep transcriptomics and accessible chromatin assays on sorted endometrial cell populations to identify genes and non-coding regulatory regions differentially activated in menstruating species. This analysis will reveal the molecular pathways, regulation networks and cellular interplay involved in uterine tissue shedding vs. reabsorption. In Aim 3, I will replace these modifications within the context of primate genome evolution: I will elucidate the mutational dynamics by which genetic novelty has emerged during the adoption of menstruation, and how the functional divergence of the endometrium compares to other reproductive and somatic tissues. This project will enhance our understanding of a key physiological trait for human reproduction as well as a dramatic example of functional innovation in the primate lineage.

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