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Financiado

Temperature Integration via Phase change and Translation Of Proteins in plants

How eukaryotes sense and integrate temperature information is an open question in biology. Plants have evolved to grow across a wide range of climates, and experience large temperature gradients geographically, seasonally and over... ver más

31/12/2026

IGZ

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

LEIBNIZINSTITUT FUR GEMUSE UND ZIERPFLANZENBA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-08-13

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2020-ADG: ERC ADVANCED GRANT

I+D

Cerrada hace 4 años

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2 Participantes

IGZ

2.14M€ | Lider

ODEL LUX

694.32K€ | Participante

Últimas noticias

02-12-2024: AGENCIA-VALENCIANA-D... En las últimas 48 horas el Organismo AGENCIA VALENCIANA D... ha otorgado 1 concesiones

02-12-2024: CDTI En las últimas 48 horas el Organismo CDTI ha otorgado 4 concesiones

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

Duración del proyecto: 64 meses Fecha Inicio: 2021-08-13
Fecha Fin: 2026-12-31

Presupuesto del proyecto 2M€

Descripción del proyecto How eukaryotes sense and integrate temperature information is an open question in biology. Plants have evolved to grow across a wide range of climates, and experience large temperature gradients geographically, seasonally and over the 24 h diurnal cycle. The distribution and phenology of plants has altered in response to climate-change, and crop yields decrease by about 10% for every 1ºC increase in temperature. The mechanisms by which plants respond to temperature are however poorly understood. We have recently discovered two major nodes for sensing temperature status by plants: (1) Transcriptional- key proteins required for plant temperature responses contain prion related domains and are directly controlled by temperature dependent phase separation. (2) Translational- transcripts show preferential translation at high temperature, and have thermoresponsive hairpin structures. Building on these discoveries, we propose an ambitious programme to understand the fundamental principles by which the cell senses and integrates temperature: (1) How do prion domain proteins sense temperature and control the activity of transcriptional regulators? What are the organising principles of their activity, and how can sequence variation such as repeat length tune and adapt thermoresponsive prion domain proteins to different climates? (Biochemistry and genetic analysis combined with high throughput functional screens) (2) How is translation affected by warm temperature? What is the RNA secondary structure code that enables certain transcripts to be preferentially translated at high temperature? (Ribo-seq, quantitative proteomics and transgenic approaches) (3) How can we use the knowledge gained above in (1) and (2) to engineer specific temperature response networks in yeast and plants? How can we create useful tools and assays to advance the field such as FRET biosensors for local temperature within the cell? (Bioinformatics, biochemistry and cell biology)

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