ChoiceSpace
Financiado
Task-relevant cognitive maps and their role in spatial decision-making
One of the hallmarks of our cognition is the ability to decide by thinking several steps ahead using an internal cognitive map. In the wild, map-based decisions can enable animals to select a target location based on the amount of...
One of the hallmarks of our cognition is the ability to decide by thinking several steps ahead using an internal cognitive map. In the wild, map-based decisions can enable animals to select a target location based on the amount of food available and the cost of reaching there. But how are such decisions made? For example, how does the brain evaluate a nearby location with a small amount of food versus a distal location with more food? What if the route to the distal location is steep? Such spatial decisions are unique because evaluating a location depends not only on the learned properties of the location but also on inferred properties, like distance, that are estimated from an internal map. However, where or how in the brain are these maps stored and how they enable spatial decision-making remains unknown. Here we will address this question through three specific aims. First, we will test how animals choose among reward sites located at various distances, each dispensing different reward amounts. Next, we will investigate how animals deduce the costs and benefits associated with different trajectories in an environment to make an informed decision. Finally, we will decipher how these internal cognitive maps are formed. These questions will be studied using novel behavior paradigms with rats as the animal model. As rats perform these tasks, simultaneous activity of hundreds of neurons will be recorded from multiple brain regions using novel custom-built devices. To study the internal map formation and the mechanism of map-based decision-making, the neural activity will be analyzed using state-of-the-art machine learning techniques. Finally, the causal role of the corresponding brain regions in spatial decision-making will be tested using optogenetic perturbation experiments. This multi-disciplinary approach will uncover how the brain makes map-based spatial decisions – a phenomenon that remains unexplored but yet of great importance across species.
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Duración del proyecto: 62 meses
Fecha Inicio: 2024-01-31
Fecha Fin: 2029-03-31
Fecha Fin: 2029-03-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-01-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2023-STG:
ERC STARTING GRANTS
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
1M€
Líder del proyecto
THE HEBREW UNIVERSITY OF JERUSALEM
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5