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Targeting the cancer stem cell CSC metabolism with designed reactive metal co...

Targeting the cancer stem cell CSC metabolism with designed reactive metal complexes Designed, bulky metal complexes with a labile coordination position react with accessible guanines at G4 DNA quadruplexes, promoting changes in their conformation and function. Importantly, we have found that this selective reacti... see more

28/02/2022

USC

150K€

Project Budget: 150K€

Project leader

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 238

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2022-02-28

ERC-2019-POC: ERC Proof of Concept Grant Scope:Eligible Countries

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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3 Participantes

USC

130.00K€ | Leader

EUROCATERING FOOD SERVICE, S...

437.27K€ | participant

UAM

20.00K€ | participant

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Project duration: 23 months Date Start: 2020-03-20
End date: 2022-02-28

Project leader

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 238

Project Budget 150K€

participation deadline Sin fecha límite de participación.

Project description Designed, bulky metal complexes with a labile coordination position react with accessible guanines at G4 DNA quadruplexes, promoting changes in their conformation and function. Importantly, we have found that this selective reactivity leads to very interesting biological effects. In particular, some of these compounds are able to suppress the stem-like character of cancer stem cells, apparently by deterring their mitochondrial respiration. Preliminary experiments, including in vivo assays, confirm that these biological effects result in remarkable antitumoral activities. This proposal aims to explore the scope of the approach, confirm that the mechanism of action involves mitochondria, design more selective versions and exploit the potential of the compounds as new type of anticancer agents.

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