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ELASTISLET

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Tailored Elastin like Recombinamers as Advanced Systems for Cell Therapies in Di...

Tailored Elastin like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet Cell Niche ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial desi... see more

31/05/2019

UVA

6M€

Project Budget: 6M€

Project leader

UNIVERSIDAD DE VALLADOLID No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 1016

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2019-05-31

NMP-10-2014: Biomaterials for the treatment of d... Scope:Specific challenge: Diabetes mellitus and its associated pathologies have become a major publi...

I+D

Cerrada does 11 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

13 Participantes

UVA

1.77M€ | Leader

Promoscience

262.45K€ | participant

UNIVERSITAT BASEL

N.D. | participant

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Project duration: 48 months Date Start: 2015-05-28
End date: 2019-05-31

Project leader

UNIVERSIDAD DE VALLADOLID No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 1016

Project Budget 6M€

participation deadline Sin fecha límite de participación.

Project description ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them into a new immune-isolation and biomimetic scaffolding approach for islet and cell transplantation in diabetes treatment. ELASTISLET’s starting point is a highly innovative and versatile family of superior biomaterials, the Elastin-like Recombinamers (ELRs). Those innovative materials will be combined with the most cutting-edge encapsulation technologies, such as reactive LbL. ELASTISLET relies on the most innovative ideas taken from synthetic biology, nanobiotechnology and molecular and cellular biology to build the ideal niche for islet/cell encapsulation and transplantation. ELASTISLET main objective is to achieve a functional coating that fulfils, first, the basic requirements of optimal biocompatibility and physical properties (permselectivity) but, second, generate a capsule that can promote an intense and directed cross talk through all cell-material interfaces involved: the implant-surrounding tissue (outer) interface and cargo cells-capsule (inner) interface. At the end, a capsule that is able not only to cloak its content and isolate it from the immune rejection but that it is able to biologically interact with the surrounding tissues and its cargo simultaneously in a way that the implanted capsule will immediately interact and fuse with the surrounding tissues creating a real continuity of the extracellular matrix from the core of the capsule to the surrounding hosts tissues and procuring adequate nutrient supply. That will provide a physiologically ideal biomimetic environment for the implanted islets/cells to survive and function in the long term without perceiving a foreign, unusual or hostile environment.

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