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T Helper cell lineages and their Cytokines in Autoimmune SKin Disease

Autoimmune skin diseases like psoriasis and atopic dermatitis are in part CD4 T cell mediated. After stimulation, CD4 T cells differentiate into different T helper cell lineages with distinct cytokine profiles. While in atopic der... ver más

31/05/2014

UKHD

75K€

Presupuesto del proyecto: 75K€

Líder del proyecto

UNIVERSITATSKLINIKUM HEIDELBERG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-05-31 No tenemos la información de la convocatoria

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UKHD

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Líder del proyecto

UNIVERSITATSKLINIKUM HEIDELBERG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 75K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Autoimmune skin diseases like psoriasis and atopic dermatitis are in part CD4 T cell mediated. After stimulation, CD4 T cells differentiate into different T helper cell lineages with distinct cytokine profiles. While in atopic dermatitis for example skin infiltrating T cells mainly show a Th2-polarization, in psoriasis, which is mediated by autoreactive T cells of the Th1-phenotype, recent evidence indicates an important pathogenic role for Th17 cells. However, it is not fully understood why a particular disease setting leads to a certain predominant T helper cell polarization and the consecutive skin phenotype. Given the high prevalence of psoriasis and atopic dermatitis in western countries, it is of great interest to elucidate the mechanisms of disease development and how they can be manipulated therapeutically. Previously I have shown that Scurfy mice harbor autoreactive T cells recognizing antigens in the skin and developed the Scurfy Transfer Model. In this model autoreactive CD4 T cells from Scurfy mice are transferred into RAG-/- recipients and induce skin disease within 4 weeks. Thus I am now able to transfer either naive or different types of pre-differentiated CD4 T helper cells and to analyse the resulting skin phenotype. The following questions will be addressed: Which T helper cell polarization will spontaneously occur after transfer of naïve auto-reactive T cells into RAG-/- recipients? Which factors lead to that particular development? Which skin phenotype is induced after transfer of pre-differentiated Th1, Th2, Th9 and Th17 T helper cells? Are there shared phenotypic features of the induced skin phenotype and human autoimmune skin diseases? How can T helper cell polarization be manipulated in vivo? In conclusion, the general objective of this research proposal is to evaluate the distinct skin pathologies induced by different T helper cell lineages derived from skin-autoreactive CD4 T cells in the Scurfy Transfer Model.

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