Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SYSMET

Financiado

Systems Biology of Membrane Trafficking

Membrane trafficking is fundamental for homeostasis of the internal membrane system and transport to and from the extracellular medium. Although we have gained detailed knowledge on the molecular organization of membrane trafficki... ver más

30/06/2022

FONDAZIONE TELETHO...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FONDAZIONE TELETHON ETS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-06-30

ERC-ADG-2014: ERC Advanced Grant

I+D

Cerrada hace 10 años

0% 100% 100%

2 Participantes

FONDAZIONE TELETHON ETS

2.24M€ | Lider

JAZ ZUBIAURRE

476.50K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

DeCoDe Deciphering Cellular Networks for Membrane Protein Quality C... 2M€ Cerrado

BFU2016-77728-C3-3-P HOMEOSTASIS MOLECULAR EN EL DOGMA CENTRAL: RECAMBIO DE MRNAS... 182K€ Cerrado

BFU2016-77728-C3-1-P HOMEOSTASIA Y RECAMBIO MOLECULAR EN EL DOGMA CENTRAL 303K€ Cerrado

BFU2014-52125-REDT BIOLOGIA FUNCIONAL Y DE SISTEMAS DE LA PROLIFERACION CELULAR 32K€ Cerrado

RED2018-102628-T RED ESPAÑOLA EN CANALES IONICOS 25K€ Cerrado

DynaDiff Elucidating the interplay between nuclear compartments and t... 1M€ Cerrado

Duración del proyecto: 80 meses Fecha Inicio: 2015-10-12
Fecha Fin: 2022-06-30

Líder del proyecto

FONDAZIONE TELETHON ETS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Membrane trafficking is fundamental for homeostasis of the internal membrane system and transport to and from the extracellular medium. Although we have gained detailed knowledge on the molecular organization of membrane trafficking machineries a global view of its function and regulation is lacking. To date membrane trafficking is often regarded as a constitutive process with a high degree of functional redundancy. However, the fact that mutations of single trafficking genes with ubiquitous expression give rise to tissue-specific human diseases and discrete sets of trafficking genes have differential effects on tissue development challenge this view. Here, using a combination of state-of the-art technologies, we will apply a systems biology approach in specialized cell types to establish a physiological and functional spatiotemporal map of membrane trafficking genes and proteins (membrane trafficking modules; MTMs). To this end we have curated a list of 1,187 genes representing ER, Golgi, Endosomes and Lysosomes (EGEL) around which we develop independent but interconnected approaches: (i) RNA-seq and antibody microarrays to identify co-regulated MTMs; (ii) high-content siRNA screening to define functional MTMs; (iii) epistatic functional analysis between EGEL genes and five membrane trafficking disease genes (TRAPPC2 in chondrocytes, Sec23A in osteoblasts, OCRL and CLCN5 in proximal tubular epithelial kidney cells, and VAPB in neuronal cells); and (iv) studies of protein-protein interactions to generate functional and physical networks centered on the disease genes. SYSMET will generate a unique resource by defining the impact and interplay of the different regulatory layers of the entire membrane trafficking system with important implications for human health.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores