Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

VecSyn

Financiado

Cerrado

Synthetic species of the mosquito vectors of human disease from hybrid genetics...

Synthetic species of the mosquito vectors of human disease from hybrid genetics to a new type of vector control In this project I aim to generate the first synthetic species of mosquitoes derived from Anopheles gambiae, the main vector of malaria, and also from Aedes albopictus, a vector of several viral diseases, that has recently invaded... ver más

31/01/2019

IMPERIAL COLLEGE O...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2019-01-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IMPERIAL COLLEGE OF SCIENCE...

0.00€ | Lider

Proyectos interesantes

MALVECBLOK

Medical Technol...

Biotechnology

3M€ Cerrado

BLOCKTIGER

Medical Technol...

Biotechnology

222K€ Cerrado

AnoPath

Medical Technol...

Genetics

2M€ Cerrado

ANOREP

Medical Technol...

Environmental S...

2M€ Cerrado

MOSQUITOBLOCK

Medical Technol...

Environmental S...

279K€ Cerrado

VecTrap

Medical Technol...

Data Science

280K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto In this project I aim to generate the first synthetic species of mosquitoes derived from Anopheles gambiae, the main vector of malaria, and also from Aedes albopictus, a vector of several viral diseases, that has recently invaded Europe. The experimental generation of artificial species will prove invaluable to shed light on major biological questions concerning reproductive isolation. Furthermore, I propose a novel strategy to reduce the incidence of disease transmitted by these vectors based on the release of synthetic strains. Mathematical modelling indicates this to be a highly effective way to simultaneously suppress and replace a wild disease transmitting vector population with disease-refractory insects. In Objective 1, I will identify genes that constitute the natural reproductive barriers in mosquitoes by analyzing the genetic makeup of progeny arising from crosses of related mosquito species. Such genes can be drawn upon for the construction of artificial barriers and help to reveal the mechanisms underlying speciation in mosquitoes. In Objective 2, I will introduce, into the mosquito genome, artificial reproductive barriers that cause post-zygotic lethality in hybrids but that will not otherwise affect the mating propensity of parent and synthetic species. I propose a generalizable approach for the construction of artificial species barriers utilizing synthetic transcriptional activators. In Objective 3, synthetic strains will be transformed with genes that interfere with the replication of malaria or viral pathogens and their transmission to humans and tested in cage experiments to validate their efficacy for vector control. To carry out these experimental activities I will utilize cutting-edge next generation genetic mapping and site-specific genome-editing technologies. Knowledge arising from the development of synthetic mosquito strains will be applicable to beneficial species with a range of applications in biosafety, agriculture and biotechnology.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores