Synthetic nucleic acid co transcriptional networks as diagnostic and therapeutic...
Synthetic nucleic acid co transcriptional networks as diagnostic and therapeutic tools
WHY: The heterogeneity of tumors often makes their diagnosis and treatment a very hard task. A single tumor can have many different diagnostically-relevant molecular markers which can also be used to monitor the efficacy of treatm...
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Información proyecto CO-TRANS-NET
Duración del proyecto: 62 meses
Fecha Inicio: 2024-10-07
Fecha Fin: 2029-12-31
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Descripción del proyecto
WHY: The heterogeneity of tumors often makes their diagnosis and treatment a very hard task. A single tumor can have many different diagnostically-relevant molecular markers which can also be used to monitor the efficacy of treatment. Innovative, simple, cost-effective, and quantitative analytical tools for diagnostic and therapeutic applications are urgently needed to ensure rapid and appropriate patient care.
WHAT: CO-TRANS-NET project addresses this need by developing synthetic nucleic acid units that can respond to a wide range of tumor biomarkers and can provide innovative tools for biosensing and therapeutics through cell-free in-vitro transcription.
HOW: The ground-breaking idea of CO-TRANS-NET is to harness the high programmability of synthetic nucleic acids together with the high sensitivity and versatility of cell-free systems to develop co-transcriptional networks that, in one pot, through nature-inspired recognition mechanisms, can respond to a variety of targets including proteins, small molecules and antibodies and trigger in-vitro transcription of functional RNA. The transcribed RNA can provide a measurable signal or produce a therapeutic drug. CO-TRANS-NET aims to develop single theranostic nanodevices in which cancer diagnosis and theraphy can be simultaneously achieved- This goes beyond the state of the art and represents a breakthrough in the field of diagnostics, biosensing, synthetic biology and nucleic acid-based therapeutics.